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Front. Bioeng. Biotechnol. | doi: 10.3389/fbioe.2018.00049

Dental Mesenchymal Stem Cell-Based Translational Regenerative Dentistry: From Artificial to Biological Replacement

  • 1Conservative Dentistry Department, Faculty of Dentistry, Alexandria University, Egypt
  • 2Tissue engineering laboratories, Faculty of Dentistry, Alexandria University, Egypt
  • 3Prosthodontics, Faculty of Dentistry, Alexandria University, Egypt

Dentistry is a continuously changing field that has witnessed much advancement in the past century. Prosthodontics is that branch of dentistry that deals with replacing missing teeth using either fixed or removable appliances in an attempt to simulate natural tooth function. Although such “replacement therapies” appear to be easy and economic they fall short of ever coming close to their natural counterparts. Complications that arise often lead to failures and frequent repairs of such devices which seldom allow the true physiological function of dental and oral-maxillofacial tissues. Such factors can critically affect the quality of life of an individual. The market for dental implants is continuously growing with huge economic revenues. Unfortunately, such treatments are again associated with frequent problems such as peri-implantitis resulting in an eventual loss or replacement of implants. This is particularly influential for patients having co-morbid diseases such as diabetes or osteoporosis and in association with smoking and other conditions that undoubtedly affect the final treatment outcome. The advent of tissue engineering and regenerative medicine therapies along with the enormous strides taken in their associated interdisciplinary fields such as stem cell therapy, biomaterial development, and others may open arenas to enhancing tissue regeneration via designing and construction of patient-specific biological and/or biomimetic substitutes. This review will overview current strategies in regenerative dentistry while overviewing key roles of dental stem cells particularly those of the dental pulp, until paving the way to precision/translational regenerative medicine therapies for future clinical use.

Keywords: Prosthodontics, biological replacement, dental pulp stem cells, Peri-Implantitis, translational regenerative dentistry

Received: 10 Jan 2018; Accepted: 11 Apr 2018.

Edited by:

Maddalena Mastrogiacomo, Università di Genova, Italy

Reviewed by:

Abhigyan Satyam, Harvard Medical School, United States
Eiki Koyama, University of Pennsylvania, United States  

Copyright: © 2018 El Backly and Marei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Rania El Backly, Faculty of Dentistry, Alexandria University, Conservative Dentistry Department, 13 Champolion st., Azarita, Alexandria, 21526, Alexandria, Egypt,