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Front. Bioeng. Biotechnol. | doi: 10.3389/fbioe.2018.00192

Magnetic Force-Based Microfluidic Techniques for Cellular and Tissue Bioengineering

  • 1İzmir Institute of Technology, Turkey

Live cell manipulation is an important biotechnological tool for cellular and tissue level bioengineering applications due to its capacity for guiding cells for separation, isolation, concentration, and patterning. Magnetic force-based cell manipulation methods offer several advantages, such as low adverse effects on cell viability and low interference with the cellular environment. Furthermore, magnetic-based operations can be readily combined with microfluidic principles by precisely allowing control over the spatiotemporal distribution of physical and chemical factors for cell manipulation. In this review, we present recent applications of magnetic force-based cell manipulation in cellular and tissue bioengineering with an emphasis on applications with microfluidic components. Following an introduction of the theoretical background of magnetic manipulation, components of magnetic force-based cell manipulation systems are described. Thereafter, different applications, including separation of certain cell fractions, enrichment of rare cells, and guidance of cells into specific macro- or micro-arrangements to mimic natural cell organization and function, are explained. Finally, we discuss the current challenges and limitations of magnetic cell manipulation technologies in microfluidic devices with an outlook on future developments in the field.

Keywords: magnetic manipulations, Microfluidics, rare cell separation, Cell culturing, Tissue engineeering

Received: 30 Aug 2018; Accepted: 23 Nov 2018.

Edited by:

Qasem Ramadan, Agency for Science, Technology and Research (A*STAR), Singapore

Reviewed by:

Arnaud Scherberich, University Hospital of Basel, Switzerland
Pu Chen, Stanford University, United States  

Copyright: © 2018 Yaman, Anil-Inevi, Ozcivici and Tekin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Dr. Engin Ozcivici, İzmir Institute of Technology, Urla, 35430, İzmir, Turkey, enginozcivici@iyte.edu.tr
Dr. Huseyin C. Tekin, İzmir Institute of Technology, Urla, 35430, İzmir, Turkey, cumhurtekin@iyte.edu.tr