Innovative tools for mechanobiology: unravelling outside-in and inside-out mechanotransduction
- 1University of Mons, Belgium
- 2Mechanobiology & Soft Matter group, Interfaces and Complex Fluids Laboratory, Research Institute for Biosciences, University of Mons, Belgium
Cells and tissues can sense and react to the modifications of the physico-chemical properties of the extracellular environment (ECM) through integrin-based adhesion sites and adapt their physiological response in a process called mechanotransduction. Due to their critical localization at the cell-ECM interface, transmembrane integrins are mediators of bidirectional signaling, playing a key role in « outside-in » and « inside-out » signal transduction. After presenting the basic conceptual fundamentals related to the field of mechanobiology, we review the current state-of-the-art technologies that facilitate the understanding of mechanotransduction signaling pathways. Finally, we highlight innovative technological developments that can help to advance our understanding of the molecular mechanisms involved in nuclear mechanotransduction.
Keywords: mechanobiology, Mechanotransduction, cytoskeleon, Integrins, Microsystem and macrosystem approaches, force, signaling / signaling pathways
Received: 31 Jan 2019;
Accepted: 20 Jun 2019.
Edited by:Sara Baratchi, RMIT University, Australia
Reviewed by:Gerald A. Meininger, University of Missouri, United States
Anthony J. Ricci, Stanford University, United States
Yubing Sun, University of Massachusetts Amherst, United States
Copyright: © 2019 Mohammed, Versaevel, Bruyère, Alaimo, Luciano, Vercruysse, Procès and Gabriele. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Prof. Sylvain Gabriele, University of Mons, Mons, Belgium, email@example.com