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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Bioeng. Biotechnol. | doi: 10.3389/fbioe.2019.00205

Peptide-based functional biomaterials for soft-tissue repair

  • 1University of Ottawa Heart Institute, Canada
  • 2University of Ottawa, Canada

Synthetically derived peptide-based biomaterials are in many instances capable of mimicking the structure and function of their full-length endogenous counterparts. Combine this with the fact that short mimetic peptides are easier to produce when compared to full length proteins, show enhanced processability and ease of modification, and have the ability to be prepared under well-defined and controlled conditions; it becomes obvious why there has been a recent push to develop regenerative biomaterials from these molecules. There is increasing evidence that the incorporation of peptides within regenerative scaffolds can result in the generation of structural recognition motifs that can enhance cell attachment or induce cell signaling pathways, improving cell infiltration or promote a variety of other modulatory biochemical responses. By highlighting the current approaches in the design and application of short mimetic peptides, we hope to demonstrate their potential in soft-tissue healing while at the same time drawing attention to the advances made to date and the problems which need to be overcome to advance these materials to the clinic for applications in heart, skin, and cornea repair.

Keywords: peptide, Biomateriais, Tissue engeneering, Functional material, Synthetic polymer

Received: 06 May 2019; Accepted: 09 Aug 2019.

Edited by:

Hasan Uludag, University of Alberta, Canada

Reviewed by:

Jennifer Patterson, KU Leuven, Belgium
Oscar Castano, University of Barcelona, Spain  

Copyright: © 2019 Hosoyama, Lazurko, Muñoz, McTiernan and Alarcon. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Emilio I. Alarcon, University of Ottawa, Ottawa, Canada, ealarcon@ottawaheart.ca