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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Bioeng. Biotechnol. | doi: 10.3389/fbioe.2019.00293

Recent advances in nanomaterials-based chemo-photothermal combination therapy for improving cancer treatment

Zuhong Li1,  Yangjun Chen2, Ya Yang1, Yan Yu3, Yanhong Zhang1, Danhua Zhu1, Xiaopeng Yu1*, Xiaoxi Ouyang1, Zhongyang Xie1, Yalei Zhao1 and  Lanjuan Li1, 4*
  • 1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Zhejiang University School of Medicine, China
  • 2School of Ophthalmology and Optometry, Wenzhou Medical University, China
  • 3School of Medicine, Zhejiang University, China
  • 4Zhejiang University, China

Conventional chemotherapy for cancer treatment is usually compromised by shortcomings such as insufficient therapeutic outcome and undesired side effects. The past decade has witnessed the rapid development of combination therapy by integrating chemotherapy with hyperthermia for enhanced therapeutic efficacy. Near-infrared (NIR) light-mediated photothermal therapy, which has advantages such as great capacity of heat ablation and minimally invasive manner, has emerged as a powerful approach for cancer treatment. A variety of nanomaterials absorbing NIR light to generate heat have been developed to simultaneously act as carriers for chemotherapeutic drugs, contributing as heat trigger for drug release and/or inducing hyperthermia for synergistic effects. This review aims to summarize the recent development of advanced nanomaterials in chemo-photothermal combination therapy, including metal-, carbon-based nanomaterials and particularly organic nanomaterials. The potential challenges and perspectives for the future development of nanomaterials-based chemo-photothermal therapy were also discussed.

Keywords: Cancer, nanomaterials, chemo-photothermal therapy, NIR responsive, synergistic effect

Received: 30 Jul 2019; Accepted: 09 Oct 2019.

Copyright: © 2019 Li, Chen, Yang, Yu, Zhang, Zhu, Yu, Ouyang, Xie, Zhao and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Mr. Xiaopeng Yu, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Zhejiang University School of Medicine, Hangzhou, 310003, Zhejiang Province, China, jor030750@163.com
Prof. Lanjuan Li, Zhejiang University, Hangzhou, China, ljli@zju.edu.cn