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ORIGINAL RESEARCH article

Front. Bioeng. Biotechnol.
Sec. Biomaterials
Volume 12 - 2024 | doi: 10.3389/fbioe.2024.1426477
This article is part of the Research Topic

Pharmaceutical Biomaterials

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Unveiling the Mechanism of Photothermal Therapy in Acne Management: Targeting Sebaceous Gland Ferroptosis via Umbilical Cord Mesenchymal Stem Cell Membrane-Encapsulated Au-Ag-PDA Provisionally Accepted

Ronghui Wu1 Jing Li2 Hao Tian3 Dandan Song1 Tianqi Zhao1 Yangyang Tian1 Christos C. Dr. Zouboulis4 Jinlan Jiang2* Mingji Zhu1*
  • 1Department of Dermatology, China-Japan Union Hospital, Jilin University, China
  • 2Scientific Research Center, China-Japan Union Hospital of Jilin University, China
  • 3Department of Orthopedics Surgery, China-Japan Union Hospital of Jilin University, China
  • 4Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Germany

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Background: Branched gold and silver nanoparticles coated with polydopamine (Au-Ag-PDA) demonstrate high photothermal conversion efficiency. Utilizing umbilical cord mesenchymal stem cell membranes (MSCM) as an effective drug delivery system, our preliminary studies investigated the suppression of sebum secretion in sebaceous glands using MSCM-coated Au-Ag-PDA nanoparticles(Au-Ag-PDA@MSCM) combined with 808 nm laser irradiation, showing potential for dermatological applications in acne treatment. Methods: This study employs proteomic analysis, complemented by subsequent techniques such as Western blotting (WB), small interfering RNA (siRNA), and transmission electron microscopy, to further investigate the differential mechanisms by which Au-Ag-PDA and Au-Ag-PDA@MSCM-mediated photothermal therapy (PTT) suppress sebum secretion. Results: Our proteomic analysis indicated mitochondrial respiratory chain damage in sebaceous gland tissues post-PTT, with further validation revealing ferroptosis in sebaceous cells and tissues. Acyl-CoA Synthetase Long-Chain Family Member 4 (Acsl4) has been identified as a 删除[熊猫人]: critical target, with Au-Ag-PDA@MSCM demonstrating enhanced ferroptotic effects. Conclusion:These findings significantly advance our understanding of how PTT mediated by Au-Ag-PDA@MSCM nanoparticles reduces sebum secretion and underscore the pivotal role of MSCM in inducing ferroptosis in sebaceous glands, thus providing a robust theoretical foundation for employing PTT via specific molecular pathways in acne treatment.

Keywords: Proteomics, Au-Ag-PDA@MSCM, photothermal therapy, ferroptosis, Acne, ACSL4

Received: 01 May 2024; Accepted: 20 May 2024.

Copyright: © 2024 Wu, Li, Tian, Song, Zhao, Tian, Dr. Zouboulis, Jiang and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Prof. Jinlan Jiang, Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun, Hebei Province, China
Mx. Mingji Zhu, Department of Dermatology, China-Japan Union Hospital, Jilin University, Changchun, China