Open Platform Concept for Blockchain-Enabled Crowdsourcing of Technology Development and Supply Chains

We outline the concept of an open technology platform that builds upon a publicly accessible library of fluidic designs, manufacturing processes, and experimental characterization, as well as virtualization by a “digital twin” based on modeling, simulation, and cloud computing. Backed by the rapidly emerging Web3 technology “Blockchain,” we significantly extend traditional approaches to effectively incentivize broader participation by an interdisciplinary “value network” of diverse players. Ranging from skilled individuals (the “citizen scientist” and the “garage entrepreneur”) and more established research institutions to companies with their infrastructures, equipment, and services, the novel platform approach enables all stakeholders to jointly contribute to value creation along more decentralized supply chain designs including research and technology development (RTD). A blockchain-enabled token economy efficiently leverages the “Wisdom of the Crowds” and secures “trust” and transparency by reputation systems requiring “skin in the game” from contributors. Prediction markets are created for guiding decision making, planning, and allocation of funding; competitive parallelization of work and its validation from independent participants substantially enhances quality, credibility, and speed of project outcomes in the real world along the entire path from RTD, fabrication, and testing to eventual commercialization. This novel, Blockchain-backed, open platform concept can be led by a corporation, academic entity, a loosely organized group, or even “chieflessly” within a smart-contract encoded Decentralized Autonomous Organization (DAO). The proposed strategy is particularly attractive for highly interdisciplinary fields like microfluidic Lab-on-a-Chip systems in the context of manifold applications in the Life Sciences. As an exemplar, we outline the centrifugal “Lab-on-a-Disc” technology. Rather than engaging in all sub-disciplines themselves, many smaller, highly innovative actors can focus on strengthening the product component distinguishing their unique selling point (USP), e.g., a particular bioassay, detection scheme, or application scenario. In this effort, system integrators access underlying commons like fluidic design, manufacture, instrumentation, and software from a more resilient and diversified supply chain, e.g., based on a verified pool of community-endorsed or certified providers.


INTRODUCTION
It is now widely recognized that manufacturing "value chains, " including initial design, testing, and optimization stages, to production ramp-up and in-use activities are critical in transforming new technologies and ideas into marketable products. However, how best to manage critical network resources in the design and setup of enabling (yet often) "nascent" supply chains is poorly understood and executed. Forming and growing a "resilient" supply chain should be a critical component in the design of a platform-based business model.
In such platform-based strategies that have been widely adopted by mature industries like automotive since the latter part of the 1970s (Muffatto, 1999), a wide range of products are derived from a joint, modular architecture so components, processes, and services can be shared internally and/or with suppliers. Such streamlined approaches accelerate, de-risk, and reduce costs for research and technology development (RTD), and subsequent manufacture and configurability of new products; related formal or internal standards also allow forging comprehensive RTD capabilities and supply chains composed of specialist players as a hallmark of modern, task-sharing economies. The availability of a critical market size and diversity of its members constitutes a key prerequisite for such platform strategies; otherwise, the setup cost for such a generalized approach would be excessive, the risk high, and, hence, the overall incentive for (independent) parties to embark rather low.
The distributed ledger technology (DLT) "Blockchain" (Nakamoto, 2009;Yaga et al., 2018) has already proven to afford a high level of trust and transparency to financial transactions for fueling collaboration in the digital world; its "smart contracts" are mostly executed on the [nearly (Miller, 2016)] Turing-complete "Ethereum Virtual Machine" (EVM) (Buterin, 2014) without the need for a middleman. Beyond blockbuster Bitcoin and decentralized finance ("DeFi"), our new approach expands the concept of Blockchain-endowed trust to the real world of product development for crowdsourcing of work, expertise, infrastructure, forecasting, and services along the entire pipeline from idea generation, funding, RTD, and production and marketing.
Among the wide scope of applications, this paper exemplifies the implementation and benefits of the novel, blockchainbacked open platform concept for "Lab-on-a-Chip" systems. The primary commercial use cases of these microfluidic devices are biomedical in vitro diagnostics (IVD) at the point-of-care (PoC), tools for life-science (research), monitoring industrial processes, infrastructures, and the environment. The present global market for such microfluidic devices and products is valued well above 10 billion USD (Status of the Microfluidics Industry, 2019).
Conventional platform concepts (Ducrée and Zengerle, 2004) and standards (Klapperich, 2009;Stavis, 2012;van Heeren, 2012;Tantra et al., 2016;Reyes et al., under review) have already been suggested for such Lab-on-a-Chip systems. However, the vast majority of these microfluidics-based products still addresses comparatively small niche markets for which it is extremely hard to leverage economy-of-scale effects to recover upfront investment, e.g., for setting up RTD and production; nevertheless, companies are still quite hesitant to share their technology portfolio outside their own contract suppliers. This paper first outlines the basics of open platform models for the representative case of the modular, centrifugal microfluidic "Lab-on-a-Disc" (LoaD) platform. It then elaborates present bottlenecks for wider-scale commercial success of this special variant of Lab-on-a-Chip technology. Next, "Wisdom of the Crowd" mechanisms in connection with their blockchainbased implementation powered by crypto-economically enabled reputation schemes 11 are elaborated. With the final summary, we discuss further synergies, opportunity, and challenges.

PLATFORMS
Technology platforms create a variety of applications, e.g., to address different market segments, from a common set of design rules, materials, processes, components, and development tools. Prominent examples are car platforms (e.g., Volkswagen Group, Toyota, GM, Fiat, Mitsubishi, Ford, Mazda, Chrysler, Hyundai-Kia) defining essential architecture such as floorplan, wheelbase, steering mechanism, suspensions, and wheelbase 12 . Economy-of-scale effects markedly reduce cost (per unit) of RTD for the product and production technologies, and lower the number of parts in the inventory, promote quality, enhance reliability, enable customization, and facilitate logistics. Computing platforms provide an environment for executing programs; there are different levels, such as browsers, program suites, operating systems, software, hardware, and combinations thereof 13 (Böttcher, 2018).
In strictly proprietary platforms, these core elements are sourced internally, or from designated contract suppliers who are bound to confidentiality and/or exclusivity. This restrictive policy can be lifted by publishing standards, e.g., for component interfaces or test methods, to attract more players and thus to create choice for buyers and to relax the dependence of specialized suppliers from a single organization; yet, certain key enabling intellectual property (IP) including know-how may remain confidential, e.g., kept as a trade secret by an internal group or filed as patent, to shield the product against competition. In any case, the formation of such platforms vitally requires the involvement of a critical mass of participants and a matching market demand. Therefore, it is much easier for established, large-scale industries and their conglomerates to organize a "closed" supply chain.
Open platforms release information needed to participate in the RTD and supply chain to pro-actively stimulate the engagement of multiple parties, thus inducing crucial economyof-scale effects for seminally augmenting quality, speed, and cost. Especially smaller, highly innovative system integrators can thus efficiently outsource essential elements, such as materials, manufacture, and specialized services, to a commercial network while leaving sufficient room to distinguish their own value proposition and USPs, e.g., their distinctive methods or application spaces. The benefits of such open platform approaches are likely to significantly outweigh drawbacks such as loss of IP on common aspects of the product that may be shared with competitors.

EXAMPLE: LAB-ON-A-DISC Technology
In the wide arena of microfluidic systems, platform concepts (Ducrée and Zengerle, 2004) and related standards (Klapperich, 2009;Stavis, 2012;van Heeren, 2012;Tantra et al., 2016;Reyes et al., under review) have been propagated for quite a while. Applications are mostly found in the context of the life sciences, in particular for sample-to-answer systems for biomedical point-of-care and global diagnostics, liquid handling automation, process analytical techniques, and cell line development for biopharma as well as monitoring the environment, infrastructure, industrial processes, and agrifood. In the context of global virus outbreaks, Lab-on-a-Chip systems have been developed for rapid patient screening, e.g., in the context of the current Covid-19 pandemic (McRae et al., 2020;Tymm et al., 2020;Zhuang et al., 2020).
To further illustrate the extended, open platform concept presented in this paper, we consider the specific use case of centrifugal microfluidic systems that have been developed by many commercially 13,14,15,16,17 and academically (Schembri et al., 1992(Schembri et al., , 1995Madou and Kellogg, 1998;Johnson et al., 2001;Honda et al., 2005;Andersson et al., 2007;Clime et al., 2015Clime et al., , 2019Malic et al., 2015;Thompson et al., 2016;Krauss et al., 2019) driven initiatives since the 1990s. On these LoaD systems (Figure 1), liquid samples and reagents are pumped and conditioned by a centrifugal field that is modulated by the spin rate of the rotor. While a variety of geometrical formats of microfluidic chips that display a network of miniaturized chambers and interconnecting channels have been utilized, a disc of similar size as optical storage media (e.g., CD, DVD, or Blu-Ray) is still a common shape.
Its exceptional capability of larger-scale (functional) integration (LSI) on the LoaD enables comprehensive sampleto-answer automation and parallelization for "point-of-use" scenarios as a critical USP with major markets in bioanalytical point-of-care diagnostics, tools for life-science research, and the biopharmaceutical industry. A "White Paper"-type document is currently issued as a foundational element to encourage and enable broad participation of RTD communities and supply chains. In particular, "digital twin" concepts (Grieves and Digital, 2017) in connection with widely available cloud computing will shift the emphasis from experimental to in silico design optimization, and thus massively open up participation in crowdsourcing of RTD.
Modularity, whether by hardware or design, constitutes a key enabler for platform strategies. On a component level, the LoaD features an instrument that is essentially assembled from a simple spindle motor, electronic control, and (mostly optical) detection units; this "player" receives a typically singleuse (polymer) cartridge that fully contains the sample and reagents, while safely retaining potentially (bio-)hazardous waste; the contact-free, rotationally induced pressurization of the chipbased liquids supersedes the need for maintenance-prone fluidic or pneumatic interfaces to the player. The variant of the LoaD platforms considered here (Ducrée et al., 2007;Steigert et al., 2007;Böning et al., 2008;Mark et al., 2009;García-Cordero et al., 2010;Godino et al., 2012;Gorkin et al., 2012;Dimov et al., 2014;Kinahan et al., 2014Kinahan et al., , 2015Kinahan et al., , 2016Burger et al., 2015;Mishra et al., 2015;Brennan et al., 2017;Delgado et al., 2018) also allows a second level of modularization where assay protocols are run in a batch-wise "stop-and-go" fashion along a sequence of Laboratory Unit Operations (LUOs), such as metering, mixing, and particle filtering, each of which is independently controlled by a rotationally actuated, normally closed valve at its interconnecting outlet.
Similar to common lumped-element models for electronic circuitry, a layout can be well-represented by a network of parallel 13 Abaxis. Available online at: https://www.abaxis.com/ 14 Gyros Protein Technologies. Available online at: https://www. gyrosproteintechnologies.com/ 15 Blusense Diagnostics. Available online at: https://blusense-diagnostics.com/ 16 LaMotte Chemical Products Co. Available online at: https://www.lamotte.com 17 Biosurfit (2020). Available online at: https://www.biosurfit.com/ FIGURE 1 | Lab-on-a-Disc (LoaD) systems feature a modular setup of a single-use, polymer chip, often of similar geometry as common optical storage media like CD, DVD, or Blu-ray, which features a network of chambers for batch-wise conditioning of (bio-)samples and reagents. These chambers represent Laboratory Units Operations (LUOs) such as metering, mixing, aliquoting, purification, concentration, and particle separation, which are sequentially processed in a batch-wise fashion along a conventional laboratory protocol through normally closed valves placed at their interconnecting channels.
or serially connected fluidic equivalents of resistors, capacitors, inductances, diodes, relays, and routers that are powered by voltage or current sources. By virtue of their functionally modular architecture, LoaD systems can hence be described and simulated by lumped-element models where LUOs and valves are characterized by reduced-dimension transfer functions. Importantly, the availability of accurate modeling of liquid handling on the LoaD allows one to directly derive component performance and reliability from geometrical tolerances related to device manufacture to rapidly raise Technology Readiness Levels (TRLs) (Ducrée, 2020).
The modular setup and predictability of fluidic function from basic manufacturing tolerances creates a sound basis for crowdsourcing of RTD. In addition, and similar to mature industries such as electronics and Micro Electro Mechanical Systems (MEMS), capable supply chains can be built around foundries to significantly accelerate, de-risk, and economize the development of new applications.

Supply Chain
With modularity of its foundational technologies and scope applications, LoaD systems are particularly amenable to the platform concept. However, in line with other emerging industry-type examples, e.g., "plastic electronics, " that are often characterized by new and innovative manufacturing processes driven by individual actors and new enterprises (Harrington and Srai, 2016), single-handed development is still prevalent among start-up companies in the arena of microfluidics.
Given the specialist nature and a limited pool of suppliers in terms of, e.g., specialized manufacture, the current modus operandi is to carry out contract work under strict confidentiality or exclusivity arrangements. As well as failing to take advantage of technological synergies and economies-of-scale, the underlying risk is that one becomes merely "reactive" in response to competitor strategies (Santos and Eisenhardt, 2009;Hills and Sarin, 2015). In the absence of widely accepted standards, a platform-based mechanism paired with blockchain-enabled incentivization schemes presented here can boost market driving strategies where an actor or enterprise may proactively influence the competitive landscape and industry standards (Jaworski et al., 2000;Kumar et al., 2000).
Concerns on sharing IP and trade secrets have been addressed by blockchain-enabled refined data management and also by permissioned (Singh, 2019), e.g., federated or consortium, blockchains 18,19 , which add a control layer to restrict access and participation. The legacy corporate culture is also rooted in the huge variety of underlying microfluidic concepts, often requiring development from scratch for most of their technological constituents. Actors and small emerging firms then focus their efforts on resolving associated technical issues and developing prototypes while early "non-technical" requirements are often overlooked.
As a result, research in the area of emerging industries has typically concentrated on the technology side, coupled with particular technology-specific commercialization challenges. However, the "industrial ecosystem" is much more complex, and cannot be readily described by a single viewpoint (Harrington and Zhang, 2017). For example, it is argued that emergence is largely dependent on the parallel development of a "new" supply chain or network to flank such commercialization activities (Sebastiao and Golicic, 2008). Yet, the design, setup, and operation of enabling supply chains, in the context of emerging industries, is poorly understood. One key challenge is the lack of a defined strategy that a firm can follow due to the uncertainty, FIGURE 2 | Exemplary pipeline from idea to a unique microfluidic, e.g., "Lab-on-a-Disc" product. The proprietary part underpinning the Unique Selling Points (USPs) comprises of the original idea of an assay protocol, its reagents, or application including specific optimization cost, performance, productization, and marketing; the embedded, shared part comprises of a library of fluidic designs, testing, and manufacturing methods that are sourced from a common, multi-party RTD and supply chain, e.g., following foundry-type business models that are, for instance, well-proven in the electronics/MEMS (Ersland and Somisetty, 2012) 15 or photonics (Khan et al., 2019) industries.
which often forces entrepreneurs to experiment with multiple choices for supply chain designs (Sarasvathy, 2001).
For example, supplier identification has both a longand short-term impact on supplier selection and the performance of entire supply chains (Lasch et al., 2005). This selection process can be very time-consuming-leading to increased time-to-market and making it difficult to maintain (or achieve) critical "first mover advantage" (Sarasvathy, 2001). Consequently, identification and compilation of an appropriate pool of trusted suppliers have become an integral part of the supplier selection process (Govindan et al., 2018).
The proposed open platform concept can contribute to improve management of critical network resources in the setup of enabling "nascent" supply chains and allow system integrators to access shared assets (e.g., fluidic design, manufacture, instrumentation, and software) from more resilient supply chain setups (a verified pool of certified suppliers enabled by an open platform concept).
Even though there have been significant success stories in the world of microfluidic technologies, many projects are smothered by completely underestimated costs of bespoke facilities for (manufacturing) scale-up; it is typically only realized in retrospect that greater numbers of microfluidic devices, ideally produced by the eventual mass fabrication scheme, are required well before eventual market entry to optimize and properly validate functional reliability with sound statistics and consistent assay performance toward passing internal quality checks and regulatory compliance (Ducrée, 2019).  (Khan et al., 2019), this model is likely to stimulate the formation of foundries that provide digital-twin supported designfor-manufacture (DfM) for delivering highly predictable functionality of components and devices. The responsibility for such "commons" is thus taken from the shoulders of innovative system integrators who can align their resources on progressing their ring-fenced competitive edge, e.g., on behalf of their distinctive know-how on bioassays or their applications and market access.

"WISDOM OF THE CROWDS"
The idea that collective intelligence tends to supersede the quality of individual assessment was pushed since the early 2000s (Surowiecki, 2004). This section reviews instances where "Wisdom of the Crowds" principles have been successfully applied in the social Web2.0 and science to pave the way for its implementation for crowdsourcing of work, expertise, infrastructure, and services for RTD projects in the next section on related blockchain technologies.

Social Web
Already in the social Web 2.0, "wisdom of the crowds" has been extensively implemented, e.g., in social media (e.g., "likes, " "followers") and online shopping (e.g., ratings and comments by buyers and sellers), which, as a positive knock-on effect, also boost customer engagement (Yoon and Youn, 2016;Tan et al., 2017). Especially in dearth of other objective sources, information obtained from the crowd can be very useful, and many portals have managed to widely suppress manipulation. For instance, tapping into the crowd has also proven to be very useful for aggregating information on the "state of the world, " e.g., real-time updates on transport networks or footfall in local shops; even emerging pandemics such as Covid-19 have been identified and reported at a very early stage 21 (Brownstein and Freifeld, 2007;McKenna, 2020).

Finding "Truth" in Science and RTD
The need for decision making in absence of "absolute truth" particularly applies to the realm of projects in science and RTD, which coarsely follow a sequence of conception, planning, evaluation, implementation, and exploitation. In principle, all these phases are susceptible to subjectivism, misjudgement, undeliberate error, and even deceit, whether from the originators or their assessors. Here, we briefly survey truth finding schemes for projects in the commercial and academic domains, which will then be ported to Blockchain in the subsequent section.
In the corporate world, RTD is often carried out within a closed circle of workers, managers and assessors (Figure 3). The technological idea or application case is based on an (assumed) understanding of a functional principle or market context. With the funding raised, staff is hired and resources for product development and its commercial exploitation procured, which is monitored by the stakeholders and boards appointed by them. Truth finding at the root of decision making is thus based by "skin in the game" of investors, management, and employees, e.g., in terms of assets, stock options, career opportunities, or salaries.
In science, a panel of uninvolved peers evaluates the proposal, its implementation plan, and the appropriateness of requested funding. Upon their positive review, a designated group of (internal) researchers, e.g., recruited from a closed research group or consortium, runs the project and disseminates its outcomes within the scientific community.
Transparent documentation of materials, methods, and results is at the heart of finding "truth" in academic publishing (Baldwin, 2018), where a two-stage process is usually enacted: upon submission, journal editors appoint independent experts to assess the quality and originality of the manuscript. Post acceptance, the entire scientific community is invited to validate the paper, so flawed or fabricated results are quickly disguised, especially on topics of wider-ranging relevance. Other than in the commercial world, errors mainly affect scholarly reputation rather than leading to financial penalties, so that legal sanctions are mostly enforced for gross misconduct or deliberate fraud. Compared to the commercial RTD path displayed in Figure 2, primarily the validation stage is crowdsourced in academia.

BLOCKCHAIN TOOLBOX
Having its origin in the first popular cryptocurrency Bitcoin launched by the famous white paper authored in 2009 by the pseudonymous individual or group "Satoshi Nakamoto" (Nakamoto, 2009;Sharma, 2019), blockchain technology has already impressively succeeded to implement financial transactions on its cryptographically safeguarded DLT. Boosted a few years later by the release of EVM (Buterin, 2014), which can execute smart contracts , a plethora of projects continue to break new grounds in "DeFi" (Leonhard, 2019). Opinions of investors on the solidity and prospects of "crypto" tend to largely diverge (Suberg, 2020).
A broad range of commercial projects on advancing blockchain technologies are driven by companies and foundations 14,22 (see text footnote 16,23 ); even more, projects pursuing goals that are shared by communities, referred to as "Commons, " are carried out by a diverse range of loosely organized groups of volunteers. Management, governance and arbitration are enacted by a blockchain-backed token economy for stake-based decision making 8 . In the same spirit as permissionless access and decentralization, the blockchain community also seeks to extend the trust without middleman community to encode entire Decentralized Autonomous Organizations (DAOs) in smart contracts. These "DAOs" 8,24,25,26,27,28,29 (Vigna, 2016) bear great promise to (self-) organize conception, fundraising, selection, management, monitoring, and governance.
As a key advantage, Blockchain supports funding of projects by seigniorage (Craig and Kachovec, 2019), or the privilege to issue new money, typically in the form of project-specific initial coin offerings (ICO), which issue asset tokens 30 that may be traded against other crypto-or fiat currencies at various exchanges, or for other purposes such as voting rights in liquiddemocracy governance 31 or for settling blockchain utility fees. Yet, there are still some regulatory issues to be addressed 32 .
Establishing trust at the heart of blockchains themselves relies on crowd-based "skin in the game" mechanisms referred to as proof-of-work and (delegated) proof-of-stake, respectively. In the meantime, the blockchain community has created an ample ecosystem reaching beyond the social Web2.0 encompassing formalized reputation and staking schemes 2,39 , idea promotion 40 , bounties 5 , TBCs 41 (Goro, 2018), and curation markets (de la . They incentivize objective vetting of experts via their immutable track record on reputation and community-based validation of technological concepts.

CROWDSOURCING Project Structure
We now outline how the previously introduced "Wisdom of the Crowds" and reputation systems trustfully and 36 CHAINLINK. Available online at: https://chain.link/ (accessed July 24, 2020). 37 IOTA Foundation. Available online at: https://www.iota.org/ (accessed July 24, 2020). 38 Non-Fungible Token. Available online at: https://en.wikipedia.org/wiki/Non-fungible_token 39 Numerai. Available online at: https://numer.ai/ (accessed August 28, 2020). 40 Ideamarket.io. Available online at: https://ideamarket.io/ 41 Molecule.to. Available online at: https://molecule.to/ (accessed July 24, 2020). transparently implemented by Blockchain technologies can be synergistically combined to organize projects on open technology platforms with the example of LoaD. As opposed to a linear project in Figure 2, in such an RTD project, as represented in Figure 4, the smart-contract and skin-in-the-game-backed open platform allows one to tap into the crowd across all stages of value creation and decision making.
Similar to architectural competitions, initial idea generation, e.g., an internal team, can be boosted by inputs from a vast pool of clever brains. Blockchain provides timestamping such IP on its unforgeable and immutable ledger, and smart contracts can establish and implement clear-cut rules for participation, e.g., on shares of future revenues or license royalties. Skin-in-the-game schemes staking cryptoassets or reputation (tokens) in prediction markets 2,5,42,43 can then support sound planning including the required investment, which might also be raised by crowdfunding mechanisms, e.g., seigniorage and minting crypto-economical assets.

Competitive Parallelization
For the following RTD phase and the supply chain, much of the work, expertise, infrastructure, and services, at least the parts that are uncritical for the USP of the eventual product, should be crowdsourced on the basis of an open platform model. 42 Stox.com. Available online at: https://www.stox.com/ (accessed July 27, 2020). 43 Gnosis.io. Available online at: https://gnosis.io/ (accessed July 27, 2020). FIGURE 4 | Involvement of the "Crowd" along the entire value creation from idea to delivery and exploitation. Energized by a blockchain-implemented token economy, prediction markets for planning are backed by collective intelligence while work and validation on RTD and supply chain are crowdsourced through competitive parallelization as outlined in the green-framed box and further illustrated in Figure 5.
While trust in accompanying financial transactions is assured by "programmable money" in the form of smart contracts on the (e.g., Ethereum) blockchain, the best possible "truth" on outcomes in the physical world, e.g., as feeds for decision making algorithms called "oracles" 44,45,46 encoded on the blockchain, is found through competitive parallelization of deliverables and their validation (Figure 5).
In more detail, the deliverable of a work package (WP) should be described, as much as possible, by objectively assessable criteria such as quantitative Key Performance Indicators (KPIs) and associated methods of their characterization. These descriptors are posted to prompt a "race" for rewards or bounties attracting offers from (independent) players. Buyers may then select a subset of these proposals for concurrent execution. Their deliverables are then evaluated and ranked, e.g., by holders of governance tokens, and then remunerated with crypto-assets according to a pre-defined, transparent scheme that is immutably recorded on the blockchain.
At first glance, the parallelized approach in Figure 5 seems to be more costly than the linear scheme in Figure 3. This would certainly hold when assuming equal work efficiencies among both approaches. However, experience, especially when projects involve academic partners on public grants, tells that running a highly diverse interdisciplinary project with an internal team often leads to significant gaps in competences and delays on deliverables, especially in the technologies that reside outside the participant's main technological or commercial enablers.
To give a simplified example, crowdsourcing competence leaders at triple rate of an internal resource significantly enhances quality and accelerates delivery by a factor of 10, so charging a given WP to three expert players in parallel is likely to deliver at roughly the same overall cost, while substantially improving quality, credibility, and speed of delivery. It is acknowledged that competitive parallelization might not bode well with traditional funding schemes, investors, and phases of projects, e.g., during seed funding of early stage start-ups.
Bestowed with the "trust" and "truth" through the blockchain and streamlining by the open platform concept, participation in RTD and supply chains is not restricted to full-fledged organizations; it rather reaches out to talent, knowledge, and workforce of non-institutionalized individuals, e.g., through "hackathons" 48 or "citizen science" 49 . Fast emerging trends like decentralized 50 for making "things" (Birch, 2019), e.g., by 3D printing, cloud-based access to software, supercomputing, artificial intelligence (AI), Big Data solutions 51,52 , and real-time 5G communication network, are likely to further globalize and somewhat democratize value creation. 48 Hackathon. Available online at: https://en.wikipedia.org/wiki/Hackathon 49 Foldit. Available online at: https://fold.it/ (accessed July 24, 2020). 50 Fab Labs (2020). Available online at: https://www.fablabs.io/ (accessed July 24, 2020). 51 AWS -Amazon Web Services. Available online at: https://aws.amazon.com/ 52 Google Cloud. Available online at: https://cloud.google.com/ FIGURE 5 | Competitive parallelization. A system integrator or buyer crowdsources the work, e.g., on RTD or manufacture from independent players. The buyer selects a subgroup of players according to their offers. The outcomes are ranked, as much as possible, by a validation panel according to quantitative Key Performance Indicators. Bidders can increase their chance of acceptance by staking while quality work is rewarded by assets and reputation.

Platform Strategies for Supply Chain Resilience, Responsiveness, and Reconfigurability
The blockchain-backed open platform concept follows strong movements in globalization and regulation, in addition to advances in digitalization and data analytics, which are generating business opportunities in terms of novel value creation 53 . These drivers have formed an environment in which many firms are encountering new challenges and opportunities in traditional supply chain practices, for instance, in enhancing their resilience, responsiveness, and reconfigurability. A common thread recently emphasized by leading international multinational corporations (e.g., Cisco, Coca-Cola, Jaguar, and Land Rover) is the need to connect, network, and collaborate across supply chains-in developing a "cleverer together" operating philosophy, in designing supply chains to be more agile and customer-focused, in exploiting the potential of digitalization (e.g., blockchain for governance), and in addressing the environmental impact of existing supply chain designs (Harrington, 2015). This is now further influenced by the complexities of the "new normal, " as such firms struggle to assess and rebuild their global supply chains after COVID-19 (Betti and Ni, 2020).
One area of focus is to develop open platform strategies for (re-)distributed manufacturing (RDM), i.e., "the ability to personalize product manufacturing and deployment at multiple scales and locations, be it at the point of consumption, sale, or within production sites" (Srai et al., 2016b) to promote supply chain resilience, responsiveness, and reconfigurability. RDM can also have a democratizing effect on participation at a socio-economic level (Srai et al., 2016a). Here, new "Circular Economy 4.0" operating principles have been developed that capture the interplay between digital technologies and circular supply chain designs based on centralized-semicentralized-decentralized configurations (Tsolakis et al., 2020). In promoting free access to, e.g., "asset libraries" of manufacturing processes and simulation methods, these configurations and operating principles lend themselves to open technology platforms for the crowdsourcing of supply chain including RTD, through Blockchain. This is in line with moves toward interdisciplinary approaches involving "innovation ecosystems" of diverse actors-ranging from skilled individuals (the "citizen scientist"; the "garage entrepreneur") and a new type of freelance researcher to more emerging small and medium enterprises (SMEs) and well-established firms. Economic activity does not necessarily translate to direct support of "micro-innovators, " for example, in do-it-yourself (DIY) biotechnology-type RTD contexts 54 . Hence, open platform strategies can advance the emergence of a network of entrepreneur archetypes to collectively solve intractable challenges, by drawing on the philosophies of "open science" (Smart et al., 2019) and "collective intelligence" (Malone and Bernstein, 2015).
Our blockchain-backed open platform concept features important aspects of both RDM and the "innovation ecosystem, " such as providing access to local resources, exemplified by enhanced user participation across technology development, fabrication, and supply. These mechanisms are typically enabled by digitalization, virtualization, and new production (and analytical) technologies. We extend RDM by crowdsourcing upfront RTD and inclusion of non-corporate entities, e.g., empowering citizen science communities to avail of a resilient supply chain network of assets.

Challenges and Solutions
There are still various bottlenecks that stymie a seminal breakthrough of blockchain technologies. In the public eye, the volatility of cryptocurrencies represents a critical downside; meanwhile, a number of stablecoins have been issued, which are hard-or soft-pegged to fiat currencies 20,55,56,57,58 . Also, solutions to increase scalability, transaction throughput 59,60 (Bitcoin Cash, 2020;Bitcoin SV, 2020;Mearian, 2020), interoperability 27,61 , and compliance with financial regulators (Hussey, 2019; The LAO, 2019) have been developed.
Scamming, exploits, malicious attacks, and poor governance constitute major setbacks for any project. Blockchain has already suffered, e.g., through the notorious hack of "The DAO" (Ð), the biggest crowdfunded project at its time having raised over $150 million from its more than 10,000 supporters (Siegel, 2016;Vigna, 2016) in 2016. Since then, smart contract security and other mitigation techniques have been massively improved, and even larger projects and DAOs raising several billion dollars have been launched 62 (Rooney, 2018).
Most USPs of blockchain application are difficult to convey to the wider public, and participation often goes through user interfaces, such as decentralized applications ("DApps") 65, 66 , which may only be handled by possessing a certain level of technological understanding. This limits the creation of a critically sized user base for which the operation of blockchain concepts make sense (Zhu and Iansiti, 2019). For similar reasons, it is difficult to provide test beds including a larger number of players that sufficiently represent all facets of the real-world user base (Harrington et al., 2018;Skowronski and Benton, 2018). There is good progress on simulation tools 67 .
Furthermore, institutional anchoring and compliance with existing legal frameworks, e.g., on corporate structure, equity, and taxation, are, for the most part, not solved in a satisfactory fashion, yet 68 (The LAO, 2019). Still, there are various governments evaluating their benefits and options for their legal embedding 69 (see text footnote 24,70 ).
With the growing awareness for protecting the global ecosphere, there is somewhat valid public concern regarding the sizeable power consumption underpinning the protection of first-generation blockchains by "Proof of Work"; alternative "Proof-of-Authority" 25 , "Proof of Stake, " or more sophisticated "Delegated Proof of Stake" 71 , whether in public or permissioned blockchains, decisively reduce the environmental impact and aim to curb occasionally surging utility fees (O'Neal, 2020). Also, scalability issues that seem to be somewhat intrinsic to many first-generation blockchain technologies are well-known and addressed at high priority, e.g., through transient compartmentalization ("sharding") (Mearian, 2020), side chaining , and offline operation ("Lightning network") 46 .

SUMMARY, CONCLUSIONS, AND OUTLOOK
This paper synergistically combines a blockchain-endowed token economy for finding trust and truth rooted in skinin-the-game, collective intelligence, prediction markets, and competitive parallelization mechanisms with an open platform strategy. The novel approach for value creation and supply chain formation is exemplified by the LoaD platform where it harmonizes technology development for efficient crowdsourcing of ideas, RTD, validation, infrastructure, equipment, processes, and services from a wide range of participants including corporations, institutions, and individuals. The strategy is particularly suited for accelerating and de-risking commercialization of highly interdisciplinary applications by smaller players requiring early investment and fast innovation for rapid market entry.
In addition to their implementation by companies or research organizations, such RTD projects may also be managed in the form of a DAO that is entirely run by a crowd of stakeholders through blockchain-enabled tools for governance and arbitration. Apart from commercial objectives, such DAOs have also been suggested for grassroots-driven non-for-profit initiatives on global Commons 72 , e.g., in the context of disaster prevention like pandemics or "Saving the Planet" . They also well-align with trends such as new models of collaboration and RDM, globalization, democratization, 72 SEEDS. Available online at: https://joinseeds.com/ (accessed July 24, 2020). decentralization of value creation, data ownership, access and exploitation, and the future or work.
With all prospects, the advancement, validation, and convergence of its underlying technologies, packaging the resulting potential benefits into a compelling message to the general, presently widely uninformed, confused or just apathetic public is urgently required. Also tapping into decisive economies-of-scale effects still represents a major bottleneck to the wider-scale breakthrough of blockchain beyond DeFi.

DATA AVAILABILITY STATEMENT
The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author/s.