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Perspective ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Cell Dev. Biol. | doi: 10.3389/fcell.2019.00257

Some Questions and Answers About the Role of Hox Temporal Collinearity in Vertebrate Axial Patterning.

  • 1Faculty of Science, Leiden University, Netherlands

The vertebrate anterior-posterior (A-P = craniocaudal) axis is evidently made by a timing mechanism. Evidence has accumulated that tentatively identifies the A-P timer as being or involving Hox temporal collinearity. Here, I focus on the two current competing models based on this premise. Common features and points of dissent are examined and a common model is distilled from what remains. This is an attempt to make sense of the literature.

Keywords: Hox genes; , time space translation; , axial patterning;, gastrulattion, Stem Cells, Hox-Hox interactions, BMP-anti BMP

Received: 05 Sep 2019; Accepted: 16 Oct 2019.

Copyright: © 2019 Durston. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mx. Antony Durston, Faculty of Science, Leiden University, Leiden, Netherlands,