Impact Factor 5.206 | CiteScore 4.82
More on impact ›

Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Cell Dev. Biol. | doi: 10.3389/fcell.2019.00282

Mitochondria in Embryogenesis: an Organellogenesis Perspective

  • 1Université de Lausanne, Switzerland
  • 2Nestle Institute of Health Sciences (NIHS), Switzerland

Organogenesis is well characterized in vertebrates. However, the anatomical and functional development of intracellular compartments during this phase of development remains unknown. Taking an organellogenesis point of view, we characterize the spatiotemporal adaptations of the mitochondrial network during zebrafish embryogenesis. Using state of the art microscopy approaches, we find that mitochondrial network follows three distinct distribution patterns during embryonic development. Despite of this constant morphological change of the mitochondrial network, electron transport chain supercomplexes occur at early stages of embryonic development and conserve a stable organization throughout development. The remodeling of the mitochondrial network and the conservation of its structural components go hand-in-hand with somite maturation; for example, genetic disruption of myoblast fusion impairs mitochondrial network maturation. Reciprocally, mitochondria quality represents a key factor to determine embryonic progression. Alteration of mitochondrial polarization and electron transport chain halts embryonic development in a reversible manner suggesting developmental checkpoints that depend on mitochondrial integrity. Our findings establish the subtle dialogue and co-dependence between organogenesis and mitochondria in early vertebrate development. They also suggest the importance of adopting subcellular perspectives to understand organelle-organ communications during embryogenesis.

Keywords: morphogenes, Sonic Hedgehog (Shh), Somite, Myomaker, electron transport chain, supercomplexes, Mitochondria fusion, mitochondria fission, FCCP, Zebrafish

Received: 08 Jul 2019; Accepted: 31 Oct 2019.

Copyright: © 2019 Arribat, Grepper, Lagarrigue, Richard, Gachet, Gut and Amati. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Francesca Amati, Université de Lausanne, Lausanne, 1015, Vaud, Switzerland, francesca.amati@unil.ch