AUTHOR=Moore Rachel E. , Clarke Jon , Alexandre Paula TITLE=Protrusion-Mediated Signaling Regulates Patterning of the Developing Nervous System JOURNAL=Frontiers in Cell and Developmental Biology VOLUME=8 YEAR=2020 URL=https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2020.579073 DOI=10.3389/fcell.2020.579073 ISSN=2296-634X ABSTRACT=
During brain development, the tissue pattern and specification are the foundation of neuronal circuit formation. Contact-mediated lateral inhibition is well known to play an important role in determining cell fate decisions in the nervous system by either regulating tissue boundary formation or the classical salt-and-pepper pattern of differentiation that results from direct neighboring cell contacts. In many systems, however, such as the