Roles of Estrogen and its Receptors in Polycystic Ovary Syndrome Provisionally Accepted
Yao Xu
Ziyi Zhang
Rongxiang Wang
Songguo Xue
Qian Ying- 1Shanghai First Maternity and Infant Hospital, China
- 2shanghai east hospital, China
- 3Obstetrics and Gynecology Hospital, Fudan University, China
Polycystic ovary syndrome (PCOS) is an endocrine disorder characterized by abnormal steroid hormone levels in peripheral blood and poor-quality oocytes. In the ovary, androgen is produced by theca cells, and estrogen is produced by granulosa cells. Androgen is converted to estrogen in granulosa cells, with cytochrome P450 aromatase as the limiting enzyme during this process. Estrogen receptors (ER) include ER alpha, ER beta, and membrane receptor GPR30. Studies have demonstrated that the abnormal functions of estrogen and its receptors and estradiol synthesis-related enzymes are closely related to PCOS. In recent years, some estrogen-related drugs have made significant progress in clinical application for subfertility with PCOS, such as letrozole and clomiphene. This article will elaborate on the recent advances in PCOS caused by abnormal expression of estrogen and its receptors and the application of related targeted small molecule drugs in clinical research and treatment.
Keywords: estrogen, estrogen receptor, Ovary, Polycystic Ovary Syndrome, estrogen signaling
Received: 03 Mar 2024;
Accepted: 21 May 2024.
Copyright: © 2024 Xu, Zhang, Wang, Xue, Ying and Jin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Mx. Yao Xu, Shanghai First Maternity and Infant Hospital, Shanghai, China