Regulation of the Nrf2/HO-1 Axis by Mesenchymal Stem Cells-Derived Extracellular Vesicles: Implications for Disease Treatment Provisionally Accepted
Hua Su- 1Xingyi City People's Hospital, China
- 2Fifth Affiliated Hospital of Zhengzhou University, China
This comprehensive review inspects the therapeutic potential of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) across multiple organ systems. Examining their impact on the integumentary, respiratory, cardiovascular, urinary, and skeletal systems, the study highlights the versatility of MSC-EVs in addressing diverse medical conditions. Key pathways, such as Nrf2/HO-1, consistently emerge as central mediators of their antioxidative and anti-inflammatory effects. From expediting diabetic wound healing to mitigating oxidative stress-induced skin injuries, alleviating acute lung injuries, and even offering solutions for conditions like myocardial infarction and renal ischemiareperfusion injury, MSC-EVs demonstrate promising therapeutic efficacy. Their adaptability to different administration routes and identifying specific factors opens avenues for innovative regenerative strategies. This review positions MSC-EVs as promising candidates for future clinical applications, providing a comprehensive overview of their potential impact on regenerative medicine.
Keywords: mesenchymal stem cell, Extracellular vesicle, exosome, Nrf2, HO-1 Formatted: Left, none, Space Before: 0 pt, After: 8 pt
Received: 08 Mar 2024;
Accepted: 06 May 2024.
Copyright: © 2024 Su, Wang, Zhou, Liu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Dr. Hua Su, Xingyi City People's Hospital, Xingyi, China