AUTHOR=Dimopoulou Athina , Manta Stella , Parmenopoulou Vanessa , Kollatos Nikolaos , Christidou Ourania , Triantakonstanti Virginia V. , Schols Dominique , Komiotis Dimitri TITLE=An easy microwave-assisted synthesis of C8-alkynyl adenine pyranonucleosides as novel cytotoxic antitumor agents JOURNAL=Frontiers in Chemistry VOLUME=3 YEAR=2015 URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2015.00021 DOI=10.3389/fchem.2015.00021 ISSN=2296-2646 ABSTRACT=

We describe the synthesis of C8-alkynyl adenine pyranonucleosides 4, 5, and 8-phenylethynyl-adenine (II), via Sonogashira cross-coupling reaction under microwave irradiation. Compounds 4e and II were less cytostatic than 5-fluorouracil (almost an order of magnitude) against murine leukemia (L1210) and human cervix carcinoma (HeLa) cells, while the same compounds proved to be more active than 5-fluorouracil against human lymphocyte (CEM) cells.