%A Moni,Lisa %A De Moliner,Fabio %A Garbarino,Silvia %A Saupe,Jörn %A Mang,Christian %A Basso,Andrea %D 2018 %J Frontiers in Chemistry %C %F %G English %K Multicomponent reactions (MCRs),Diversity oriented synthesis,combinatorial libraries,Scaffold diversity,isocyanides %Q %R 10.3389/fchem.2018.00369 %W %L %M %P %7 %8 2018-September-06 %9 Original Research %# %! DOS libraries via Ugi-5C-4CR %* %< %T Exploitation of the Ugi 5-Center-4-Component Reaction (U-5C-4CR) for the Generation of Diverse Libraries of Polycyclic (Spiro)Compounds %U https://www.frontiersin.org/articles/10.3389/fchem.2018.00369 %V 6 %0 JOURNAL ARTICLE %@ 2296-2646 %X An Ugi multicomponent reaction with chiral cyclic amino acids, benzyl isocyanide and cyclic ketones (or acetone) has been exploited as key step for the generation of peptidomimetics. After a straightforward set of elaborations, the peptidomimetics were converted into polycyclic scaffolds displaying two orthogonally protected secondary amines. Libraries of compounds were obtained decorating the molecules through acylation/reductive amination reactions on these functional groups.