AUTHOR=Golantsov Nikita E., Nguyen Hung M., Golubenkova Alexandra S., Varlamov Alexey V., Van der Eycken Erik V., Voskressensky Leonid G. TITLE=Three-Component Reaction of 3-Arylidene-3H-Indolium Salts, Isocyanides, and Alcohols JOURNAL=Frontiers in Chemistry VOLUME=7 YEAR=2019 URL=https://www.frontiersin.org/articles/10.3389/fchem.2019.00345 DOI=10.3389/fchem.2019.00345 ISSN=2296-2646 ABSTRACT=A novel isocyanide-based multicomponent synthesis of alkyl aryl(indol-3-yl)acetimidates has been established. Starting from aryl(indol-3-yl)methylium tetrafluoroborates, aromatic isocyanides and alcohols, the imidates were obtained in moderate to very good yields. Consecutive four-component synthesis of the above mentioned imidates from N-alkylindoles, aromatic aldehydes, aromatic isocyanides and alcohols was also proposed. In addition, it was shown that in the presence of water, aryl(indol-3-yl)methylium tetrafluoroborates reacted with isocyanides to furnish aryl(indol-3-yl)acetamides.