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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Chem. | doi: 10.3389/fchem.2019.00531

A mild, fast and scalable synthesis of substituted α-acyloxy ketones via multicomponent reaction using a continuous flow approach.

  • 1University of Brasilia, Brazil

A continuous flow approach for the synthesis of α-acyloxy ketone derivatives from the corresponding arylglyoxals, isocyanides and carboxylic acids is described. The target products were obtained in excellent yields in short residence times and with high purities via the first transcription of the microwave-to-flow paradigm to the isocyanide-based Passerini reaction. Furthermore, this methodology allowed a ten-fold scale-up using the same experimental conditions initially established.

Keywords: α-Acyloxy ketones, Passerini reaction, Multicomponent reactions (MCRs), Microwaves (MW), Continuous flow (CF)

Received: 25 Apr 2019; Accepted: 11 Jul 2019.

Edited by:

Alexander Dömling, University of Groningen, Netherlands

Reviewed by:

Valentine Nenajdenko, Lomonosov Moscow State University, Russia
Fabio De Moliner, Queen's Medical Research Institute, University of Edinburgh, United Kingdom  

Copyright: © 2019 Salvador and Andrade. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Carlos K. Andrade, University of Brasilia, Brasilia, 70910-900, Brazil,