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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Chem. | doi: 10.3389/fchem.2019.00682

A Tetra-PEG Hydrogel Based Aspirin Sustained Release System Exerts Beneficial Effects on Periodontal Ligament Stem Cells Mediated Bone Regeneration

 Yunfan Zhang1, Ning Ding2, Ting Zhang1, Qiannan Sun1, Bing Han1* and  Tingting Yu1*
  • 1Peking University Hospital of Stomatology, China
  • 2Dalian University of Technology (DUT), China

Bone defects, massive bone defects in particular, is still an issue clinically. Acetylsalicylic acid (ASA), also known as aspirin, has been proven to be conducive for mesenchymal stem cells osteogenic differentiation, which may be benefited for bone regeneration. In order to achieve a more appealing prognosis of bone defect, here we develop a well-defined tetra-PEG hydrogel sealant with rapid gelation speed, strong tissue adhesion and high mechanical strength. After in-situ encapsulation of aspirin, this drug-loaded tetra-PEG hydrogel possessed a sustained release, anti-inflammation and osteoinductive properties. In vitro experiments showed that the cell proliferation was slightly facilitated, and the osteogenic differentiation was notably augmented when periodontal ligament stem cells (PDLSCs) were co-incubating with the hydrogel materials. Moreover, in vivo study manifested that the aspirin sustained release system significantly facilitated the PDLSCs mediated bone defect regeneration. Overall, tetra-PEG hydrogel-based aspirin sustained release system is applicable not only for enhancing the osteogenesis capacity of PDLSC but also providing a new thought of bone regenerative therapy.

Keywords: Hydrogel, drug delivery system, Periodontal ligament stem cell, Bone Regeneration, Aspirin

Received: 20 Aug 2019; Accepted: 01 Oct 2019.

Copyright: © 2019 Zhang, Ding, Zhang, Sun, Han and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Dr. Bing Han, Peking University Hospital of Stomatology, Beijing, 100081, Beijing Municipality, China, kqbinghan@bjmu.edu.cn
Dr. Tingting Yu, Peking University Hospital of Stomatology, Beijing, 100081, Beijing Municipality, China, tiffanyutt@126.com