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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Chem. | doi: 10.3389/fchem.2019.00692

Andrastone A from the Deep-Sea-Derived Fungus Penicillium allii-sativi Acts as an Inducer of Caspase and RXRα-Dependent Apoptosis

 Chun-Lan Xie1, Jin-Mei Xia1,  Ting Lin2, Ying-Jie Lin1, Yu-Kun Lin1, Man-li Xia1,  Haifeng Chen2,  Zhuhua Luo1, Zongze Shao1 and  Xian-Wen Yang1*
  • 1Third Institute of Oceanography, State Oceanic Administration, China
  • 2School of Pharmaceutical Sciences, Xiamen University, China

Two new (1, 2) and one known (3) meroterpenoids were isolated from the deep-sea-derived fungus Penicillium allii-sativi. The relative structures of new compounds were determined on the basis of extensive analysis of the NMR and MS data. And the absolute configurations were established by ECD calculations. Andrastone A (1) was a rare andrastin bearing an unusual cyclopentan-1,3-dione. It showed selectively antiproliferative effect against HepG2 tumor cells with an IC50 value of 7.8 μM. Mechanism study showed that apoptosis via Caspase and RXRα pathways were responsible for the inhibitory effect.

Keywords: deep-sea, Meroterpenoids, microorganisms, anti-tumor, Nuclear Receptors

Received: 16 Jul 2019; Accepted: 07 Oct 2019.

Copyright: © 2019 Xie, Xia, Lin, Lin, Lin, Xia, Chen, Luo, Shao and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Xian-Wen Yang, Third Institute of Oceanography, State Oceanic Administration, Xiamen, China, yangxianwen@tio.org.cn