Channel Confinement of Aromatic Petrochemicals via Aryl–Perfluoroaryl Interactions With a B←N Host

We report channel confinement properties of an electron-deficient boron host derived from the orthogonal B←N interaction between a boronic ester and trans-pentafluorostilbazole. The boron host forms one-dimensional channels in the crystalline solid state when crystallized with common electron-rich aromatic petrochemicals (i.e., benzene, toluene, o-xylene) to form solvates and a cocrystal with stilbene. Molecular confinement of the electron-rich molecules in the solids is achieved through a combination of aryl–perfluoroaryl interactions (π-πF) and hydrogen bonds.


INTRODUCTION
Host-guest chemistry is widely considered a landmark of supramolecular chemistry and focuses on uses of non-covalent interactions to hold together multicomponent molecular aggregates (Steed and Atwood, 2013;Xiao et al., 2019a,b). In the context of crystal engineering, hosts that provide the ability to confine guests into channel-type architectures have received increased attention due to intriguing properties (e.g., catalysis Yang et al., 2006, dynamics Wu et al., 2019, photoconduction Quintel and Hulliger, 1999, sorption Lim et al., 2008, and separation Chen et al., 2013Barton et al., 2019). Channel formation in transmembrane ionic transport is a vital process for living cells (Haynes and Gale, 2011). However, in contrast to the large number of natural and synthetic inorganic zeolites (Ramamurthy and Eaton, 1994;Tabacchi, 2018), there is a significant lower number of purely-organic molecules identified as reliable channel-formers in closed-packed systems (e.g., calixarene, phenylacetylene, tetraphenylethylene, triazine building blocks) (Moore, 1997;Langley and Hulliger, 1999;Dalgarno et al., 2007;Couderc and Hulliger, 2010;He et al., 2011;Huang et al., 2019;Lin et al., 2019). Understanding the formation of open cavities or channels in organic systems is essential for the development of extended systems such as Hydrogen-Bonded Organic Frameworks (HOFs) (Helzy et al., 2016;Karmakar et al., 2016) and Covalent Organic Frameworks (COFs) (Feng et al., 2012;Xu et al., 2016). SCHEME 1 | (A) Self-assembly of be-pf-sbz⊃guest from be and pf-sbz in the presence of a guest. (B) Aromatic guests in this study. (C) Formation of channels in the solid state.
As part of our efforts to investigate boron-based host materials (Herrera-España et al., 2015;Campillo-Alvarado et al., 2018c), we report the synthesis and channel confinement properties of a highly electron-deficient adduct (be-pfsbz) (Scheme 1A). The boron host be-pf-sbz is primarily sustained by a B←N bond between phenylboronic acid catechol ester (be) and trans-pentafluorostilbazole (pfsbz). The purpose of this work is to evaluate solid-state confinement of π-electron-rich molecules commonly employed in the petrochemical industry [benzene (ben), toluene (tol), o-xylene, (o-xyl)] (Scheme 1B) using be-pf-sbz. The alkene stilbene (sbn) is also studied as a guest. Aryl-perfluoroaryl interactions (π-π F ) (Coates et al., 1998;Sinnwell et al., 2015;Martínez-Vargas et al., 2017) and hydrogen bonds assist the confinement of petrochemicals into electron-deficient channels (Scheme 1C). To the best of our knowledge, our work represents the first example of a discrete B←N adduct that consistently generates channeltype architectures in the solid state upon self-assembly with guests. A related and previous example of organoboron channel former employs the hydrogen bonding capacity of tetraboronic acids to achieve channel-type architectures (Fournier et al., 2003).

Generation of Solvate-Based Channels
Our strategy to form host-guest materials involves the coordination of be and pf-sbz to generate an electron-deficient adduct. The boron adduct would then enable the confinement of π-rich aromatic guests through π-π F interactions. Frontiers in Chemistry | www.frontiersin.org FIGURE 1 | X-ray structure be-pf-sbz⊃ben: (A) stacking involving T-shaped adducts be-pf-sbz⊃ben, (B) p-pF, C-H···p, and van der Waals interactions in bc-plane, and (C) channel formation along a-axis.
To test our general hypothesis, be (30 mg, 0.1530 mmol) was added to a vial containing pf-sbz (41.5 mg, 0.1530 mmol) in ben (2 mL). The vial was heated until the solution adopted a clear red coloration. Orange single crystals formed as plates after 2 days of slow evaporation (see Supplementary Material for additional experimental information). 1 H NMR spectroscopy revealed the composition of crystals to be be-pf-sbz ⊃ben (see Supplementary Figure 1 for 1H NMR of single crystals).
A scXRD analysis of be-pf-sbz ⊃ben demonstrates the components of the solid to crystallize in the monoclinic space group P2 1 /n (see Supplementary Table 1 for crystallographic parameters). The asymmetric units consist of a molecule of both be-pf-sbz and ben (Figure 1). The stilbazole pf-sbz is coordinated to be through a B←N bond [1.674(3) Å] forming a discrete T-shaped adduct. The tetrahedral character of boron (THC = 71.7%) (Höpfl, 1999) shows the strength of the B←N bond to be comparable to similar adducts (Cruz-Huerta et al., 2016;Campillo-Alvarado et al., 2019). The fluorinated alkene adopts a twisted conformation (29.3 • ), while the pyridyl ring lies approximately orthogonal (89.7 • ) to the best plane of atoms C1, O1, and O2. Importantly, a ben molecule resides within one-dimensional (1D) channels along a, being sustained though face-to-face π-π F interactions with the perfluoroaryl ring of be-pf-sbz (centroid···centroid = 3.745 Å). The channels are defined by adjacent complexes in such a way that a cavity containing two ben molecules related by an inversion center is formed ( Figure 1A). The ben guests occupy 25.1% (i.e., contact surface) of the unit cell volume and are distributed within the channels that run along the a-axis ( Figure 1B). The channels are further sustained by C-H···π interactions and van der Waals contacts from ben and the aryl ring of an adjacent be-pf-sbz molecule ( Figure 1C).
Generality of the channel forming properties of bepf-sbz was confirmed when tol and o-xyl were used as crystallization solvents. Both solvents were confined in the crystal lattice as observed by scXRD analysis of single crystals (orange prisms) (Figure 2) and shown indirectly by 1 H NMR spectroscopy.

Generation of Cocrystal-Based Channels
The integration of a solid as a guest with be-pf-sbz was realized using sbn as the coformer.
Specifically, be (30 mg, 0.153 mmol) and pf-sbz (41.5 mg, 0.153 mmol) were dissolved in a solution of acetonitrile (2 mL) containing sbn (13.79 mg, 0.077 mmol). The vial was heated until the solution adopted a clear red coloration. Single crystals of be-pf-sbz⊃sbn in the form of orange plates were observed after 2 days of slow evaporation.
A scXRD analysis revealed the components of be-pf-sbz⊃sbn to crystalize in the monoclinic space group P2 1 /n (Figure 3) (see Supplementary Table 2 for crystallographic parameters). The asymmetric unit consists of one molecule of be-pf-sbz and one-half molecule of sbn. The larger B←N bond distance (1.802(4) Å) and smaller THC (64.8 • ) of be-pf-sbz⊃sbn is indicative of the channel confinement of the rigid guest sbn to result in a weaker B←N interaction (Höpfl, 1999). The coplanarity (8.6 • ) and orthogonality (89.5 • ) of the host effectively maximize the π-π F interactions with sbn (centroid···centroid = 4.013 Å) and establish additional π-π N contacts (centroid···centroid = 4.110 Å). Thus, sbn acts in turn as a coplanar channel "template" (Langley and Hulliger, 1999) (Figure 3A). Additional edge-to-face C-H···π interactions of be-pf-sbz sustain sbn in channels along the a-axis (Figure 3B). Although the overall packing is close to being isostructural with be-pf-sbz⊃ben [sbn occupies the same unit cell volume (25.1%)], the total cell volume increases by approximately 160 A 3 , in agreement with the higher molecular mass of sbn.

Generation of Apohost
When m-and p-xylene xylenes were used as crystallization solvents, the formation of prohost be-pf-sbz was observed vs. a solvate. Single crystals in the form of pale-yellow plates of pure be-pf-sbz were obtained by slow evaporation of a p-xylene solution (2 mL) of be (30 mg, 0.153 mmol) and pf-sbz (41.5 mg, 0.153 mmol).
A scXRD analysis revealed be-pf-sbz to crystallize in the monoclinic space group P2 1 /c with a single molecule of be-pf-sbz in the asymmetric unit (Figure 4). The B←N bond [1.678 (4) Å] and THC (71%) are similar to bepf-sbz solvates. The fluorinated alkene exhibits a twisted conformation (16.6 • ) less orthogonal (84.4 • ) to C1, O1, and O2 of be vs. the solvates and cocrystal ( Figure 4A). Notably, be-pf-sbz molecules display a herringbone arrangement primarily sustained by π-π F interactions (centroid··· centroid = 3.676 Å) between the electron-deficient region of (i.e., fluorinated alkene) and the catecholate motif of an adjacent molecule. Bifurcated C-H···F contacts further form chains along the c-axis (Figures 4B,C). The presence of destabilizing C-F···π contacts (Vangala et al., 2002) is also observed. The self-assembly behavior of be-pf-sbz in the presence of m-and p-xylenes likely reflects inadequate surface area of the guests (Swift et al., 1998;Couderc and Hulliger, 2010), which effectively prevents the formation of a crystalline channel architecture. Hartree-Fock calculations (3-21G basis set) of the three xylene isomers revealed oxyl to be effectively more compact (surface area: 146.2 Å 2 , volume: 134.3 Å 3 ) than m-and p-xylenes (surface areas: 149.4 and 149.6 Å 2 , volumes: 134.7 and 134.8 Å 3 , respectively) owing to the shorter separation between the methyl groups.

Inclusion Behavior: Complementarity and Conformational Flexibility
To shed further light on the inclusion behavior of bepf-sbz, Hartree-Fock calculations (3-21G basis set) were performed using the data from the X-ray experiments (Figure 5). Molecular electrostatic potential (MEP) surfaces revealed pf-sbz to be composed of a combination of Frontiers in Chemistry | www.frontiersin.org relatively electron-rich (pyridyl) and electron-deficient (Farene) rings (i.e., polarized charge distribution). Upon coordination with be, both rings are electron-deficient and generate two potential aromatic recognition sites (Wakamiya et al., 2006) (Figure 5A). The inclusion behavior displayed by be-pf-sbz can, thus, be attributed to the coordination to the B-atom having triggered the interactions with the electron-rich guests ( Figure 5B). We note that the addition of fluorine to organic molecules has been exploited to achieve formation of inclusion complexes (Reichenbächer et al., 2005;Berger et al., 2011).
The inclusion behavior of be-pf-sbz contrasts B←N adducts with bipyridines. The ditopic B←N adducts generate completely enclosed cavities vs. channels owing to the presence of edge-to-face π···π interactions with additional boronic esters (Campillo-Alvarado et al., 2018c. The generation of porous extended frameworks based on the B←N interactions has been recently explored (Cruz-Huerta et al., 2012;Stephens et al., 2019).
The diversity of the included guests can be attributed to the conformational flexibility of be-pf-sbz. The supramolecular allosteric nature of the host is evidenced by an overlay of the Xray molecular structures of be-pf-sbz (Figure 6) from the five solids. Changes in twist angle of the fluorinated alkene [2.6 • (be-pf-sbz⊃o-xyl)−29.3 • (be-pf-sbz⊃ben)] effectively serve to optimize π-π F interactions with guests while the boronate ester moiety acts as both a stator and "hinge" by providing additional sites for C-H···π and van der Waals interactions (see Supplementary Table 3 for selected supramolecular interactions of crystals). The observed significant contribution of the guest to the crystal packing of be-pf-sbz is reminiscent of the design of inorganic zeolites and other nanostructured materials  Frontiers in Chemistry | www.frontiersin.org FIGURE 6 | Molecular overlay of be-pf-sbz in the X-ray structures of: be-pf-sbz (black), be-pf-sbz⊃ben (blue), be-pf-sbz⊃o-xyl (green), be-pf-sbz⊃tol (orange), be-pf-sbz⊃sbn (pink). (Davis et al., 1996;Holman et al., 2001). Indeed, the flexibility allows the host to "shrink-wrap" guests of appropriate size and geometry (Holman et al., 2001).

CONCLUSION
In summary, we have demonstrated that a fluorinated boron host (i.e., be-pf-sbz) supports the formation of electrondeficient channels in the solid state when crystallized with electron-rich aromatic petrochemicals (i.e., ben, tol, and oxyl) and sbn. The persistent channels in host-guest structures are sustained by a combination of face-to-face π-π F and C-H···π interactions. When m-and p-xylenes are used as crystallization solvents, the formation of the apohost is observed. Current efforts are underway to exploit the confinement properties of be-pf-sbz to generate storage and separation materials, and to achieve topochemical control in the solid state of guest.

DATA AVAILABILITY STATEMENT
All datasets generated for this study are included in the article/Supplementary Files.

AUTHOR CONTRIBUTIONS
GC-A carried out experimental work, data analysis, and writing of the original draft. MD'm and MS carried out experimental work. HH and HM-R made intellectual contributions. LM participated as the project administrator and writing of the original draft.

ACKNOWLEDGMENTS
We gratefully acknowledge Dr. Dale C. Swenson for scXRD data collection and helpful discussion, and The University of Iowa College of Liberal Arts and Sciences for a CLAS Dissertation Writing Fellowship for GC-A.