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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Chem. | doi: 10.3389/fchem.2019.00704

Electrochemical Generation and Detection of Transient Concentration Gradients in Microfluidic Channels. Theoretical and Experimental Investigations

Thomas Abadie1, 2, 3, Catherine Sella1, 2, 3, Pierre Perrodin1, 2, 3 and  Laurent Thouin1, 2, 3*
  • 1Ecole Normale Supérieure, PSL Research University, France
  • 2Centre National de la Recherche Scientifique (CNRS), France
  • 3Sorbonne Universités, France

Transient concentration gradients generated and detected electrochemically in continuous flow microchannels were investigated by numerical simulations and amperometric measurements. Operating conditions including device geometry and hydrodynamic regime were theoretically delineated for producing gradients of various profiles with tunable characteristics. Experiments were carried out with microfluidic devices incorporating a dual-channel-electrode configuration. Under these conditions, high electrochemical performance was achieved both to generate concentration gradients and to monitor their dynamics along linear microchannels. Good agreement was observed between simulated and experimental data validating predictions between gradient properties and generation conditions. These results demonstrated the capability of electrochemical microdevices to produce in situ tunable concentration gradients with real-time monitoring. This approach is versatile for the active control in microfluidics of microenvironments or chemical gradients with high spatiotemporal resolution.

Keywords: Microfluidics, Electrochemistry, concentration gradient, Diffusion, Convection, microelectrode

Received: 21 Jun 2019; Accepted: 08 Oct 2019.

Copyright: © 2019 Abadie, Sella, Perrodin and Thouin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Laurent Thouin, Ecole Normale Supérieure, PSL Research University, Paris, France, laurent.thouin@ens.fr