Chiral Diketopyrrolopyrrole-Helicene Polymer With Efficient Red Circularly Polarized Luminescence

Chiral diketopyrrolopyrrole (DPP)-helicene polymers were synthesized to develop efficient red circularly polarized (CP) light emitters. These original chiral dyes display intense electronic circular dichroism (ECD) and CP luminescence (CPL) in the far-red spectral region owing to the presence of excitonic coupling between achiral DPPs within the chiral environment of the polymeric structure. This work affords an interesting example illustrating the potential of π-conjugated helical polymers for chiral optoelectronic applications.

These new examples display intense electronic circular dichroism (ECD) in the visible region and strong red CPL with g lum = 1.4 × 10 −3 at 660 nm, associated with a high φ of ∼35 %. This first example of chiral helicene-DPP based polymer exhibits higher CPL response than the molecular chiral helicene-DPP dyes previously reported, and brings interesting aspects for the design of efficient polymeric red and near infra-red CPL emitters.
coupling was performed using enantiopure P-and M-2,15bis-(ethynyl)[6]helicene (P-and M-H6a) (Anger et al., 2012) with 3,6-bis(5-bromothiophen-2-yl)-2,5-diketopyrrolopyrrole, DPPBr 2 , respectively (Figure 2, where only P enantiomer is described) (Wu et al., 2015). While the reactions seemed to proceed efficiently, they resulted in the formation of insoluble dark blue material (p1, Figure 2). To circumvent this solubility issue, we introduced widely used branched 2-ethylhexyl (2-EH) chains on the DPP unit in place of the linear octyl ones (Huo et al., 2009;Palai et al., 2010). Although this fragment has a chiral center, we used its racemic form since a weak influence of these additional stereogenic centers is expected on the photophysical and chiroptical properties of the final polymer in diluted solution. Unfortunately, this new approach also afforded insoluble blue solid when a stoichiometric mixture of P-H6a and 2EHDPP 2 was subjected to the Sonogashira coupling conditions (p2, Figure 2). To further increase the solubility of the obtained polymer material, the helicenic fragment was also functionalized with additional linear octyloxy chains through a new synthetic pathway involving 2-(octyloxy)-4-((trimethylsilyl)ethynyl)benzaldehyde, 2, as starting material for the synthesis of the helicene fragment. Indeed, the latter was engaged in a double Wittig reaction with naphthyl-2,7-dimethylphosphonium bromide salt, 1, to give 2,7bis(2-(octyloxy)-4-((trimethylsilyl)ethynyl)styryl)naphthalene, 3, in 60% yield. The resulting cis/trans stilbene mixture was subsequently submitted to a photocyclisation reaction with propylene oxide as an acid scavenger to afford rac-2,15-bis-((trimethylsilyl)ethynyl)-4,13-bis-(octyloxy)[6]helicene (4) in 50% yield, followed by deprotection reaction of the two remaining TMS groups to yield H6(Alkoxy) 2 (Scheme 1). Fully characterized by NMR spectroscopy and mass spectrometry (see Supplementary Information), the structures of the two latters were further ascertained by X-ray crystallographic analysis (see Scheme 1 and Supplementary Information). Both rac-4 and rac-H6(Alkoxy) 2 crystallized in a P-1 space group and displayed helicity (dihedral angle between the two terminal rings) of 41.1 • and 54.4 • , respectively, which is in the range of classical carbo[6]helicenes (Gingras, 2013;Chen and Shen, 2016;Dhbaibi et al., 2019). Moreover, the lateral octyloxy chains point toward the outside of the molecules, which may disfavor the formation of polymer aggregates in solution.
Rac-H6(Alkoxy) 2 was then submitted to chiral HPLC separation to give P-(+) and M-(-) in 99 and 98.5% of ee, respectively (see Supplementary Information for detailed experimental conditions). These enantiomers, as well as the racemic compound, were finally engaged in the polymerization reaction with 2EHDPP 2 and gave expected soluble polymers which were firstly filtered over a silica plug, then further purified by size-exclusion chromatography (SEC, CHCl 3 ) before precipitated using CHCl 3 /MeOH solvent mixture to yield P-, M-, and rac-(H6DPP) n in ∼45% yield for each polymer (see Supplementary Information). These novel chiral dyes are soluble in common organic solvents such as THF, CHCl 3 , and CH 2 Cl 2 , and were characterized by 1 H NMR and SEC using a polystyrene standard in THF. The obtained NMR spectrum displays characteristic signals for both helicene and DPP starting materials: for instance, shielded H 2,11 and deshielded H 6,7 helicenic protons at 6.75 and 8.50 ppm respectively, and deshielded DPP protons H 14,15 at 9.10 ppm (see Supplementary Information). The number average molecular mass (M n ) for rac-, P-, and M-(H6DPP) n were estimated to be 6.9 × 10 3 , 5.3 × 10 3 , and 6.4 × 10 3 , respectively, which correspond to a low degree of polymerization, ca. 5-6 (helicene-DPP) units (see Supplementary Information). The thermal stability of rac-(H6DPP) n was also evaluated by thermogravimetric analysis (TGA) and resulted in an onset decomposition temperature at 300 • C with a 10% weight loss.

UV-Vis, ECD, and Electrochemical Characterizations
The ground state photophysical and chiroptical properties of DPP-helicene polymers were investigated in CH 2 Cl 2 solutions and compared with corresponding precursors and previously reported DPP(H6DPP) 2 . UV-Vis spectrum of (H6DPP) n polymer displays two main absorption signatures between 300 and 425 nm and between 530 and 675 nm that correspond to a combination of helicene and DPP transitions for the higher energy region and only from DPP transitions for the low energy part. The latter absorption region is red-shifted by 70 nm in comparison with DPP precursor, characterized by ε = 7.0 × 10 4 M −1 cm −1 at 565 nm and 35 × 10 4 M −1 cm −1 at 635 nm for 2EHDPP 2 and (H6DPP) n , respectively, resulting from the extension of the π-conjugation via the alkynyl bridges between the DPP dye and the helicene units. These observations are supported by comparison with DPP(H6DPP) 2 UV-vis spectrum, where contributions of both "DPP-helicene" and "helicene-DPP-helicene" fragments are superimposed in the red region (see Supplementary Information for additional details). Going from oligomer DPP(H6DPP) 2 to polymer (H6DPP) n does not strongly red-shift the overall absorption signature (λ max = 620 and 635 nm for DPP(H6DPP) 2 and (H6DPP) n lowest absorption bands, respectively), which suggests that electronic communication between each bis(ethynyl)DPP unit through the π-conjugated helicene is relatively limited along the polymer. The observed difference of 15 nm results probably from the presence of the electron donating octyloxy groups on the helicene fragment for (H6DPP) n .
The electrochemical behavior of (H6DPP) n was investigated by cyclic voltammetry (CV, Figure S17 and Table S1), which displays pseudo-reversible oxidation process at ca. +0.81 V and a reversible reduction one at −1.24 V vs. SCE, respectively assigned to the oxidation and the reduction of the DPP unit(s). The calculated HOMO and LUMO energy level were −5.21 eV and a LUMO level of −3.16 eV, respectively, leading to an estimated electrochemical band gap of 2.05 eV.

Unpolarized (PL) and Circularly Polarized Luminescence (CPL)
To our delight, (H6DPP) n displays intense unpolarized vibronic emission arising from the DPP-ethynyl fragment with a maximum intensity at 660 nm and a quantum yield of 35%. Interestingly, these values suggest that embedding DPP-helicene fragment within a polymer material is also an efficient strategy to make deeper red emitter while keeping a high fluorescence efficiency since DPP(H6DPP) 2 exhibits similar luminescence quantum yield (φ = 35%) but its emission is blue shifted (λ max = 650 nm). In order to rule out the possibility of charge transfer character the emission of the polymer was carried out in solvents of different polarity including toluene, tetrahydrofuran, and dichloromethane in which the polymer was fully soluble (Figure S13). A similar spectral behavior was found in these solvents with a structured signals and no significant shift of the emission spectra, indicating that the nature of the emission is mainly based on π-π * transitions localized on the DPP units. The fluorescence kinetics of the polymer was also performed at 650 nm ( Figure S14) and fits a single-exponential decay function with a decay time constant of 2.08 ns.
Regarding circularly polarized luminescence (CPL), mirrorimage spectra were also obtained for P-and M-(H6DPP) n with a maximum and a structural signature similar to unpolarized emission, highlighting the synergy of the DPPhelicene association also in the polymer chiral excited-state ( Figure 5). Moreover, g lum factor of +1.3 × 10 −3 was determined for P-(H6DPP) n , which suggests a relatively similar chiral geometry of the ground and emitting excited states (g lum /g abs = 0.72) and represents also a ca. 40% increase in comparison with (P,P)-DPP(H6DPP) 2 (g lum = + 0.9 × 10 −3 ). The obtained g lum values for polymers (H6DPP) n are in the same range of reported SOM CPL emitters (10 −4 -10 −2 ), and are among the most efficient ones for the far red and near infrared region (i.e., for λ max > 650 nm, 3 × 10 −4 < g lum < 4.3 × 10 −3 ) (Tanaka et al., 2018).

CONCLUSIONS
In summary, we have successfully prepared novel helical conjugated polymers based on the association between enantiopure carbo[6]helicene derivative and diketopyrrolopyrrole dye via the Sonogashira cross-coupling. These polymers show strong ECD signal in the visible region ( ε × 482 M −1 cm −1 at 642 nm, for P-(H6DPP) n ) and strong CPL emission response signals (g lum = +1.3 × 10 −3 at 662 nm) along with high fluorescence quantum efficiency (ϕ f = 35 %). Extending the efficiency of exciton coupling process in chiral polymers allow efficient preparation of CPL emitters deeper in the red and near-infrared region. Our results provide an alternative approach to the metalation and the push-pull functionalization methodologies to extend and to improve the chiroptical responses of the helicene molecules by taking advantages of the strong synergy between the chiral environment controlled by the helicene center and the interesting photophysical properties offered by the corresponding dye. The polymers based on the helicene unit that we presented in this work can be used as a new class of candidates for efficient CPL materials in optoelectronics and bioimaging applications.

DATA AVAILABILITY STATEMENT
All datasets generated for this study are included in the article/Supplementary Material.

AUTHOR CONTRIBUTIONS
KD and CS synthesized and characterized the molecules. MJ and NV performed the HPLC resolution. TR performed the X-ray analysis. MG performed CPL measurements. BJ, LF, and JC supervised the work, analyzed the results and wrote the manuscript.