AUTHOR=Alomairi Jaafar , Bonacci Thomas , Ghigo Eric , Soubeyran Philippe TITLE=Alterations of host cell ubiquitination machinery by pathogenic bacteria JOURNAL=Frontiers in Cellular and Infection Microbiology VOLUME=5 YEAR=2015 URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2015.00017 DOI=10.3389/fcimb.2015.00017 ISSN=2235-2988 ABSTRACT=

Response of immune and non-immune cells to pathogens infections is a very dynamic process. It involves the activation/modulation of many pathways leading to actin remodeling, membrane engulfing, phagocytosis, vesicle trafficking, phagolysosome formation, aiming at the destruction of the intruder. These sophisticated and rapid mechanisms rely on post-translational modifications (PTMs) of key host cells' factors, and bacteria have developed various strategies to manipulate them to favor their survival. Among these important PTMs, ubiquitination has emerged as a major mediator/modulator/regulator of host cells response to infections that pathogens have also learned to use for their own benefit. In this mini-review, we summarize our current knowledge about the normal functions of ubiquitination during host cell infection, and we detail its hijacking by model pathogens to escape clearance and to proliferate.