AUTHOR=Jiang Hong , Du Hong , Wang Li M. , Wang Ping Z. , Bai Xue F. 

TITLE=Hemorrhagic Fever with Renal Syndrome: Pathogenesis and Clinical Picture

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=6

YEAR=2016

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2016.00001

DOI=10.3389/fcimb.2016.00001

ISSN=2235-2988

ABSTRACT=<p>Hantaan virus (HTNV) causes hemorrhagic fever with renal syndrome (HFRS), which is a zoonosis endemic in eastern Asia, especially in China. The reservoir host of HTNV is field mouse (<italic>Apodemus agraricus</italic>). The main manifestation of HFRS, including acute kidney injury, increases vascular permeability, and coagulation abnormalities. In this paper, we review the current knowledge of the pathogenesis of HFRS including virus factor, immunity factor and host genetic factors. Furthermore, the treatment and prevention will be discussed.</p>