AUTHOR=Killackey Samuel A. , Sorbara Matthew T. , Girardin Stephen E. 

TITLE=Cellular Aspects of Shigella Pathogenesis: Focus on the Manipulation of Host Cell Processes

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=6

YEAR=2016

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2016.00038

DOI=10.3389/fcimb.2016.00038

ISSN=2235-2988

ABSTRACT=<p><italic>Shigella</italic> is a Gram-negative bacterium that is responsible for shigellosis. Over the years, the study of <italic>Shigella</italic> has provided a greater understanding of how the host responds to bacterial infection, and how bacteria have evolved to effectively counter the host defenses. In this review, we provide an update on some of the most recent advances in our understanding of pivotal processes associated with <italic>Shigella</italic> infection, including the invasion into host cells, the metabolic changes that occur within the bacterium and the infected cell, cell-to-cell spread mechanisms, autophagy and membrane trafficking, inflammatory signaling and cell death. This recent progress sheds a new light into the mechanisms underlying <italic>Shigella</italic> pathogenesis, and also more generally provides deeper understanding of the complex interplay between host cells and bacterial pathogens in general.</p>