AUTHOR=Wang Chao , Yu Zhongyang , Shi Xiaochen , Tang Xudong , Wang Yang , Wang Xueyan , An Yanan , Li Shulin , Li Yan , Wang Xuefei , Luan Wenjing , Chen Zhaobin , Liu Mingyuan , Yu Lu TITLE=Triclosan Enhances the Clearing of Pathogenic Intracellular Salmonella or Candida albicans but Disturbs the Intestinal Microbiota through mTOR-Independent Autophagy JOURNAL=Frontiers in Cellular and Infection Microbiology VOLUME=8 YEAR=2018 URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2018.00049 DOI=10.3389/fcimb.2018.00049 ISSN=2235-2988 ABSTRACT=
Triclosan (TCS) is a broad-spectrum antimicrobial agent, whose well-known antibacterial mechanism is inhibiting lipid synthesis. Autophagy, an innate immune response, is an intracellular process that delivers the cargo including pathogens to lysosomes for degradation. In this study, we first demonstrated that TCS induced autophagy in a dose-dependent manner in non-phagocytic cells (HeLa) and in macrophages (Raw264.7) and