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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Cell. Infect. Microbiol. | doi: 10.3389/fcimb.2019.00262

Pathogenesis of important virulence factors of Porphyromonas gingivalis via Toll-like receptors

 Lu Jia1, Nannan Han1,  Juan Du1, Lijia Guo1, Zhenhua Luo1 and Yi Liu1*
  • 1Capital Medical University, China

Periodontitis is a common intraoral infection and is inextricably linked to systemic diseases. Recently, the regulation between host immunologic response and periodontal pathogens has become a hotspot to explain the mechanism of periodontitis and related systemic diseases. Since Porphyromonas gingivalis (P. gingivalis) was proved as critical periodontal pathogen above all, researches focusing on the mechanism of its virulence factors have received extensive attention. Studies have shown that in the development of periodontitis, in addition to the direct release of virulent factors by periodontal pathogens to destroy periodontal tissues, over-low or over-high intrinsic immune and inflammatory response mediated by Toll-like receptors (TLRs) can lead to more lasting destruction of periodontal tissues. It is very necessary to sort out how various cytopathic factors of P. gingivalis mediate inflammation and immune responses between the host through TLRs so as to help precisely prevent, diagnose and treat periodontitis in clinic. This review summarizes the role of three most widely studied pathogenic factors produced by P. gingivalis (lipopolysaccharide, gingipains, pili) and their interactions with TLRs at the cellular and molecular level in the progress of periodontitis.

Keywords: Porphyromonas gingivalis (P. gingivalis), Toll-like Receptors (TLR), lipopolysaccharide (LPS), Gingipains, fimbriae, virulence factor, Periodontitis

Received: 16 Apr 2019; Accepted: 04 Jul 2019.

Edited by:

Fulvio Reggiori, University of Groningen, Netherlands

Reviewed by:

Laurent Gorvel, INSERM U1068 Centre de recherche en cancérologie de Marseille, France
Maribasappa Karched, Kuwait University, Kuwait  

Copyright: © 2019 Jia, Han, Du, Guo, Luo and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Yi Liu, Capital Medical University, Beijing, China,