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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Cell. Infect. Microbiol. | doi: 10.3389/fcimb.2019.00270

Salmonella pathogenicity island 1 (SPI-1) and its complex regulatory network

Lixin Lou1, Peng Zhang1, Rongli Piao1 and  Yang Wang1*
  • 1Jilin University, China

Salmonella species can infect a diverse range of birds, reptiles and mammals, including humans. The type III protein secretion system (T3SS) encoded by Salmonella pathogenicity island 1 (SPI-1) delivers effector proteins required for intestinal invasion and the production of enteritis. The T3SS is regarded as the most important virulence factor of Salmonella. SPI-1 encodes transcription factors that regulate the expression of some virulence factors of Salmonella, while other transcription factors encoded outside SPI-1 participate in the expression of SPI-1-encoded genes. SPI-1 genes are responsible for the invasion of host cells, regulation of the host immune response, e.g., the host inflammatory response, immune cell recruitment, and apoptosis, and biofilm formation. The regulatory network of SPI-1 is very complex and crucial. Here, we review the function, effectors and regulation of SPI-1 genes and their contribution to the pathogenicity of Salmonella.

Keywords: Salmonella, SPI-1, T3SS, regulation, immune response

Received: 09 Apr 2019; Accepted: 12 Jul 2019.

Edited by:

William D. Picking, University of Kansas, United States

Reviewed by:

Clayton Caswell, Virginia Tech, United States
Victor H. Bustamante, National Autonomous University of Mexico, Mexico  

Copyright: © 2019 Lou, Zhang, Piao and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Yang Wang, Jilin University, Changchun, 130012, Jilin Province, China, wyang@jlu.edu.cn