AUTHOR=Haase Tina , Börnigen Daniela , Müller Christian , Zeller Tanja 

TITLE=Systems Medicine as an Emerging Tool for Cardiovascular Genetics

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=3

YEAR=2016

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2016.00027

DOI=10.3389/fcvm.2016.00027

ISSN=2297-055X

ABSTRACT=<p>Cardiovascular disease (CVD) is a major contributor to morbidity and mortality worldwide. However, the pathogenesis of CVD is complex and remains elusive. Within the last years, systems medicine has emerged as a novel tool to study the complex genetic, molecular, and physiological interactions leading to diseases. In this review, we provide an overview about the current approaches for systems medicine in CVD. They include bioinformatical and experimental tools such as cell and animal models, omics technologies, network, and pathway analyses. Additionally, we discuss challenges and current literature examples where systems medicine has been successfully applied for the study of CVD.</p>