TY - JOUR AU - Benedetto, Daniela AU - Abawi, Masieh AU - Stella, Pieter R. AU - Nijhoff, Freek AU - Lakemeier, Maxime D. M. AU - Kortlandt, Friso AU - Doevendans, Pieter A. AU - Agostoni, Pierfrancesco PY - 2016 M3 - Hypothesis and Theory TI - Percutaneous Device to Narrow the Coronary Sinus: Shifting Paradigm in the Treatment of Refractory Angina? A Review of the Literature JO - Frontiers in Cardiovascular Medicine UR - https://www.frontiersin.org/articles/10.3389/fcvm.2016.00042 VL - 3 SN - 2297-055X N2 - Refractory angina pectoris is defined as a chronic debilitating condition characterized by the presence of chronic anginal symptoms due to a severe obstructive and/or diffuse coronary artery disease that cannot be controlled by the combination of medical therapy and/or revascularization (percutaneous or surgical). In addition, the presence of myocardial ischemia as a cause of the symptoms must have been documented. The coronary sinus reducer (CSR) is a recently introduced percutaneous device to treat patients with severe anginal symptoms refractory to optimal medical therapy and not amenable to conventional revascularization. The purpose of this review is to describe the current evidence from available studies measuring the clinical effect of the CSR implantation on the health and well-being of patients with refractory angina. ER -