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Front. Cardiovasc. Med. | doi: 10.3389/fcvm.2018.00168

Stress coping strategies in the heart: an integrated view

  • 1University of Alberta, Canada
  • 2McGill University, Canada

The heart is made up of an ordered amalgam of cardiac cell types that work together to coordinate four major processes, namely energy production, electrical conductance, mechanical work, and tissue remodeling. Over the last decade, a large body of information has been amassed regarding how different cardiac cell types respond to cellular stress that affect the functionality of their elaborate intracellular membrane networks, the cellular reticular network. In the context of the heart, the manifestations of stress coping strategies likely differ depending on the coping strategy outcomes of the different cardiac cell types, and thus may underlie the development of distinct cardiac disorders. It is not clear whether all cardiac cell types have similar sensitivity to cellular stress, how specific coping response strategies modify their unique roles, and how their metabolic status is communicated to other cells within the heart. Here we discuss our understanding of the roles of specialized cardiac cells that together make the heart function as an organ with the ability to pump blood continuously and follow a regular rhythm.

Keywords: Endoplasmic Reticulum, proteostasis, stress response, calcium homeostasis, Heart failiure

Received: 15 Aug 2018; Accepted: 02 Nov 2018.

Edited by:

Georges Nemer, American University of Beirut, Lebanon

Reviewed by:

Miguel A. Aon, National Institute on Aging (NIA), United States
Fouad Zouein, American University of Beirut, Lebanon  

Copyright: © 2018 Michalak and Agellon. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Marek Michalak, University of Alberta, Edmonton, Canada, marek.michalak@ualberta.ca