World-class research. Ultimate impact.
More on impact ›

Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Cardiovasc. Med. | doi: 10.3389/fcvm.2019.00127

Atrial fibrillation genetics update: towards clinical implementation

 Silje M. Kalstø1,  Joylene E. Siland2,  Michiel Rienstra2 and Ingrid E. Christophersen1, 3*
  • 1Department of medical research, Bærum Hospital, Vestre Viken Hospital Trust, Norway
  • 2Department of Cardiology, University Medical Center Groningen, Netherlands
  • 3Department of Medical Genetics, Faculty of Medicine, University of Oslo, Norway

Abstract
Atrial fibrillation (AF) is the most common heart rhythm disorder worldwide, and may have serious cardiovascular health consequences. AF is associated with increased risk of stroke, dementia, heart failure and death. There are several known robust, clinical risk predictors for AF, such as male sex, increasing age, and hypertension; however, during the last couple of decades, a substantive genetic component has also been established. Over the last 10 years the discovery of novel AF-related genetic variants has accelerated, increasing our understanding of mechanisms behind AF. Current studies are focusing on mapping the polygenic structure of AF, improving risk prediction, therapeutic development and patient-specific management. Nevertheless, it is still difficult for clinicians to interpret the role of genetics in AF prediction and management. Here, we provide an overview of relevant topics within the genetics of AF and attempt to provide some guidance on how to interpret genetic advances and their implementation into clinical decision-making.

Keywords: Genetics, Precision Medicine, Genome-wide association studies (GWAS), heritability, whole genome sequencing, Atrial Fibrillation

Received: 12 Jun 2019; Accepted: 12 Aug 2019.

Copyright: © 2019 Kalstø, Siland, Rienstra and Christophersen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: MD, PhD. Ingrid E. Christophersen, Department of medical research, Bærum Hospital, Vestre Viken Hospital Trust, Rud, Norway, uxchia@vestreviken.no