Recurrence of an undifferentiated pleomorphic pulmonary artery sarcoma 8 years after initial presentation : a case report Provisionally Accepted

Baudouin Bourlond^{1, 2*} Niccolo Maurizi^{1, 2} Panagiotis Antiochos^{1, 2} Ioannis Skalidis^{1, 2} Katarina Auf Der Springe³ Claire Royer^{2, 4} Pierre Monney^{1, 2} Olivier Muller^{1, 2} Mathias Kirsch^{2, 5}

• ¹Service de Cardiologie, Centre Hospitalier Universitaire Vaudois (CHUV), Switzerland
• ²Université de Lausanne, Switzerland
• ³Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital and University of Lausanne, Switzerland
• ⁴Institut Universitaire de Pathologie, Centre Hospitalier Universitaire Vaudois (CHUV), Switzerland
• ⁵Service de Chirurgie Cardiaque, Centre Hospitalier Universitaire Vaudois, Switzerland

Background: Primary cardiac tumors remain exceptionally rare, characterized by a poor prognosis.Among them, sarcomas originating in the pulmonary arteries constitute the most infrequent subgroup within primary cardiac sarcomas.Case Summary: This report presents the case of a 76-year-old female experiencing a recurrence of an undifferentiated pleomorphic intracardiac pulmonary artery sarcoma located in the right ventricular outflow tract, manifesting 8 years after initial remission. Successful outcomes were attained through a combination of surgical resection, state-of-the-art radiotherapy, and chemotherapy. This comprehensive approach proved essential for optimizing both survival and quality of life.Discussion: The unexpectedly prolonged recurrence-free survival observed in this case underscores the effectiveness of the comprehensive multimodal treatment approach outlined in the existing literature. This highlights the pivotal role of a multidisciplinary strategy in addressing primary cardiac sarcomas, particularly those arising in the pulmonary arteries.