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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Coronary Artery Disease
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1401569
This article is part of the Research Topic

Short and Long-Term Treatment Options in Patients with Acute Coronary Syndrome

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Type 2 diabetes mellitus in acute myocardial infarction: A persistent significant burden on long-term mortality Brief title: Type 2 Diabetes in acute myocardial infarction Provisionally Accepted

Frederic Bouisset1* Vincent Bataille2 François Schiele3 Etienne Puymirat4 Antoine Fayol4 Tabassome Simon5 Nicolas Danchin6 Jean FERRIERES1
  • 1Centre Hospitalier Universitaire de Toulouse, France
  • 2Association pour la Diffusion de la Médecine de Prévention (ADIMEP), France
  • 3University Hospital Jean Minjoz, Department of Cardiology, Besançon, France, France
  • 4Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Européen Georges Pompidou, Department of Cardiology; Université Paris-Descartes, France
  • 5AP-HP, Hôpital Saint Antoine, Department of Clinical Pharmacology and Unité de Recherche Clinique (URCEST), Paris, France; Université Pierre et Marie Curie (UPMC-Paris 06); INSERM U-698, France, France
  • 6Hôpital Saint-Joseph, France

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The long-term impact of type 2 diabetes mellitus (T2DM) after an acute myocardial infarction (AMI) has not been investigated in details yet. We aimed to assess the long-term impact T2DM after AMI.We analyzed the data of three nationwide observational studies from the French Registry of Acute ST-elevation and non-ST-elevation Myocardial Infarction (FAST-MI) program, conducted over a one-month period in 2005, 2010 and 2015. Patients presenting T2DM were classified as diabetic, patients presenting type 1 diabetes mellitus were excluded. We identified factors related to all-cause death at one-year follow-up and created two groups of 1897 subjects, paired on their one-year probability of death estimated by the logistic regression model.A total of 9181AMI patients were included in the analysis, among them 2038 (22.2%) T2DM.Patients with diabetes were significantly older (68.2+/-12.0 vs 63.8 +/-14.4, p<0.001) and were more likely to present a prior history of percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG) or heart failure (22.5% vs 13.0%, 7.1% vs 3.1% and 6.7 vs 3.8% respectively, p<0.001 for all). In two groups of 1897 patients matched using propensity score on their probability of death at 1 year, diabetes was still associated with long-term mortality with HR=1.30, 95%CI [1.17-1.45], p<0.001T2DM per se has an adverse impact on long-term survival after myocardial infarction: independently of the risk of short-term mortality, patients with diabetes who survived an AMI, have a 30% higher risk of long-term mortality.

Keywords: acute myocardial infarction, Acute Coronary Syndrome, Percutaneous coronary revascularization, diabetes, prognosis

Received: 15 Mar 2024; Accepted: 13 May 2024.

Copyright: © 2024 Bouisset, Bataille, Schiele, Puymirat, Fayol, Simon, Danchin and FERRIERES. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Frederic Bouisset, Centre Hospitalier Universitaire de Toulouse, Toulouse, France