AUTHOR=Gomes-Osman Joyce, Solana-Sánchéz Javier, Rogers Emily, Cattaneo Gabriele, Souillard-Mandar William, Bates David, Gomez Enrique J., Tormos-Muñoz Josep M., Bartrés-Faz David, Pascual-Leone Álvaro TITLE=Aging in the Digital Age: Using Technology to Increase the Reach of the Clinician Expert and Close the Gap Between Health Span and Life Span JOURNAL=Frontiers in Digital Health VOLUME=3 YEAR=2021 URL=https://www.frontiersin.org/articles/10.3389/fdgth.2021.755008 DOI=10.3389/fdgth.2021.755008 ISSN=2673-253X ABSTRACT=Age-related cognitive impairment (ARCI) has a profound impact on individuals, families, health care systems, and societies at large. Evidence suggests that ARCI is the consequence of underlying brain pathology. Therefore, efforts to minimize the impact of ARCI and thus closing the gap between health span and life span, which has widened in recent years, requires early detection and timely deployment of targeted, personalized interventions. Access to clinical experts is limited and technology screening and assessment methods are thus appealing. However, as traditionally implemented patients were deprived of the benefit of personalized connection with a clinician, which is particularly critical for the prescription and to ensure the adherence to and ultimate success of therapeutic interventions. We present the concept of Intelligent Technology Therapy Assistant (ITA) as a scalable solution that increases the reach of clinical experts while sustaining the personal connection between each patient and their clinician. We illustrate ITA with the “Guttman Neuro Personal Trainer”®, a tele-rehabilitation platform that provides neuropsychological evaluation and care, and the Barcelona Brain Health Initiative (BBHI) multimodal intervention coaching app, a mobile-based platform that provides lifestyle coaching support in domains related to brain health. In addition, we discuss the translation of these models to a large-scale enterprise with Linus Health. To this end, we conclude with a discussion of challenges and opportunities to move the field forward.