AUTHOR=Kozak Leslie P. TITLE=The Genetics of Brown Adipocyte Induction in White Fat Depots JOURNAL=Frontiers in Endocrinology VOLUME=2 YEAR=2011 URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2011.00064 DOI=10.3389/fendo.2011.00064 ISSN=1664-2392 ABSTRACT=
Evidence that adult humans have functional brown adipose tissue has stirred interest in the possibility that the impressive effectiveness of induction of brown adipocytes to reduce obesity in mice may be translated to the human condition. A major focus recently on the identification of signaling and transcription factor that stimulate the induction of brown adipocytes has come from transgenic and gene KO models. However, these models have created a very complex picture of the regulatory mechanisms for brown fat induction. In this review insights into the critical regulatory pathways involved in brown adipocyte induction in the retroperitoneal fat depot of mice are described from quantitative trait locus (QTL) analysis of allelic variability determining