TY - JOUR AU - Grasso, Daniel AU - Vaccaro, Maria I. PY - 2014 M3 - Review TI - Macroautophagy and the Oncogene-Induced Senescence JO - Frontiers in Endocrinology UR - https://www.frontiersin.org/articles/10.3389/fendo.2014.00157 VL - 5 SN - 1664-2392 N2 - The oncogene-induced senescence is emerging as a potent tumor suppressor mechanism and as a possible therapeutic target. Macroautophagy is intimately linked to the senescence condition setup, although its role has not been elucidated yet. Here, we discuss up-to-date concepts of senescence-related macroautophagy and evaluate the current trend of this growing research field, which has relevance in future perspectives toward therapeutic options against cancer. ER -