AUTHOR=Nässel Dick R. , Williams Michael J. 

TITLE=Cholecystokinin-Like Peptide (DSK) in Drosophila, Not Only for Satiety Signaling

JOURNAL=Frontiers in Endocrinology

VOLUME=5

YEAR=2014

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2014.00219

DOI=10.3389/fendo.2014.00219

ISSN=1664-2392

ABSTRACT=<p>Cholecystokinin (CCK) signaling appears well conserved over evolution. In <italic>Drosophila</italic>, the CCK-like sulfakinins (DSKs) regulate aspects of gut function, satiety and food ingestion, hyperactivity and aggression, as well as escape-related locomotion and synaptic plasticity during neuromuscular junction development. Activity in the DSK-producing neurons is regulated by octopamine. We discuss mechanisms behind CCK function in satiety, aggression, and locomotion in some detail and highlight similarities to mammalian CCK signaling.
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