AUTHOR=Thanasupawat Thatchawan, Glogowska Aleksandra, Burg Maxwell, Wong G. William, Hoang-Vu Cuong, Hombach-Klonisch Sabine, Klonisch Thomas TITLE=RXFP1 is Targeted by Complement C1q Tumor Necrosis Factor-Related Factor 8 in Brain Cancer JOURNAL=Frontiers in Endocrinology VOLUME=6 YEAR=2015 URL=https://www.frontiersin.org/articles/10.3389/fendo.2015.00127 DOI=10.3389/fendo.2015.00127 ISSN=1664-2392 ABSTRACT=The relaxin-like RXFP1 ligand–receptor system has important functions in tumor growth and tissue invasion. Recently, we have identified the secreted protein, CTRP8, a member of the C1q/tumor necrosis factor-related protein (CTRP) family, as a novel ligand of the relaxin receptor, RXFP1, with functions in brain cancer. Here, we review the role of CTRP members in cancers cells with particular emphasis on CTRP8 in glioblastoma.