AUTHOR=Faienza Maria Felicia, Ventura Annamaria, Colucci Silvia, Cavallo Luciano, Grano Maria, Brunetti Giacomina TITLE=Bone Fragility in Turner Syndrome: Mechanisms and Prevention Strategies JOURNAL=Frontiers in Endocrinology VOLUME=7 YEAR=2016 URL=https://www.frontiersin.org/articles/10.3389/fendo.2016.00034 DOI=10.3389/fendo.2016.00034 ISSN=1664-2392 ABSTRACT=Bone fragility is recognized as one of the major comorbidities in Turner syndrome (TS). The mechanisms underlying bone impairment in affected patients are not clearly elucidated, but estrogen deficiency and X-chromosomal abnormalities represent important factors. Moreover, although many girls with TS undergo recombinant growth hormone therapy to treat short stature, the efficacy of this treatment on bone mineral density is controversial. The present review will focus on bone fragility in subjects with TS, providing an overview on the pathogenic mechanisms and some prevention strategies.