%A Felício,João Soares
%A Oliveira,Alana Ferreira de
%A Peixoto,Amanda Soares
%A Souza,Ana Carolina Contente Braga de
%A Abrahão Neto,João Felício
%A de Melo,Franciane Trindade Cunha
%A Carvalho,Carolina Tavares
%A Lemos,Manuela Nascimento de
%A Cavalcante,Sávio Diego Nascimento
%A Resende,Fabricio de Souza
%A Santos,Márcia Costa dos
%A Motta,Ana Regina
%A Janaú,Luísa Corrêa
%A Yamada,Elizabeth Sumi
%A Felício,Karem Miléo
%D 2017
%J Frontiers in Endocrinology
%C
%F
%G English
%K Vitamin D supplementation,Diabetes kidney disease,type 1 diabetes mellitus,nephropathy,Cholecalciferol,High dose vitamin D supplementation
%Q
%R 10.3389/fendo.2017.00199
%W
%L
%M
%P
%7
%8 2017-August-14
%9 Original Research
%+ Dr João Soares Felício,University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division,Brazil,felicio.bel@terra.com.br
%#
%! Vitamin D supplementation, diabetic kidney disease, and glycemic variability in type 1 DM.
%*
%<
%T Albuminuria Reduction after High Dose of Vitamin D in Patients with Type 1 Diabetes Mellitus: A Pilot Study
%U https://www.frontiersin.org/articles/10.3389/fendo.2017.00199
%V 8
%0 JOURNAL ARTICLE
%@ 1664-2392
%X BackgroundSome studies suggest an association between diabetic kidney disease (DKD) and vitamin D (VD), but there is no data about the effect of high dose of VD on DKD in type 1 diabetes mellitus (T1DM). Our pilot study aims to evaluate albuminuria reduction in patients with T1DM supplemented with high dose of VD.Methods22 patients received doses of 4,000 and 10,000 IU/day of cholecalciferol for 12 weeks according to patient’s previous VD levels. They were submitted to continuous glucose monitoring system, 24 hours ambulatory blood pressure monitoring and urine albumin-to-creatinine ratio before and after VD supplementation.ResultsThere was a reduction of DKD prevalence at the end of the study (68 vs 32%; p = 0.05), with no changes on insulin doses, glycated hemoglobin, glycemic variability and blood pressure values. A correlation between percentage variation of VD levels (ΔVD) and albuminuria at the end of the study was presented (r = −0.5; p < 0.05). Among T1DM patients with DKD at the beginning of the study, 8/13 (62%) had their DKD stage improved, while the other five ones (38%) showed no changes (p < 0.05).ConclusionOur pilot study suggests an association between VD high dose supplementation, lower prevalence and improvement in stages of DKD in T1DM.