%A Felício,João Soares %A Oliveira,Alana Ferreira de %A Peixoto,Amanda Soares %A Souza,Ana Carolina Contente Braga de %A Abrahão Neto,João Felício %A de Melo,Franciane Trindade Cunha %A Carvalho,Carolina Tavares %A Lemos,Manuela Nascimento de %A Cavalcante,Sávio Diego Nascimento %A Resende,Fabricio de Souza %A Santos,Márcia Costa dos %A Motta,Ana Regina %A Janaú,Luísa Corrêa %A Yamada,Elizabeth Sumi %A Felício,Karem Miléo %D 2017 %J Frontiers in Endocrinology %C %F %G English %K Vitamin D supplementation,Diabetes kidney disease,type 1 diabetes mellitus,nephropathy,Cholecalciferol,High dose vitamin D supplementation %Q %R 10.3389/fendo.2017.00199 %W %L %M %P %7 %8 2017-August-14 %9 Original Research %+ Dr João Soares Felício,University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division,Brazil,felicio.bel@terra.com.br %# %! Vitamin D supplementation, diabetic kidney disease, and glycemic variability in type 1 DM. %* %< %T Albuminuria Reduction after High Dose of Vitamin D in Patients with Type 1 Diabetes Mellitus: A Pilot Study %U https://www.frontiersin.org/articles/10.3389/fendo.2017.00199 %V 8 %0 JOURNAL ARTICLE %@ 1664-2392 %X BackgroundSome studies suggest an association between diabetic kidney disease (DKD) and vitamin D (VD), but there is no data about the effect of high dose of VD on DKD in type 1 diabetes mellitus (T1DM). Our pilot study aims to evaluate albuminuria reduction in patients with T1DM supplemented with high dose of VD.Methods22 patients received doses of 4,000 and 10,000 IU/day of cholecalciferol for 12 weeks according to patient’s previous VD levels. They were submitted to continuous glucose monitoring system, 24 hours ambulatory blood pressure monitoring and urine albumin-to-creatinine ratio before and after VD supplementation.ResultsThere was a reduction of DKD prevalence at the end of the study (68 vs 32%; p = 0.05), with no changes on insulin doses, glycated hemoglobin, glycemic variability and blood pressure values. A correlation between percentage variation of VD levels (ΔVD) and albuminuria at the end of the study was presented (r = −0.5; p < 0.05). Among T1DM patients with DKD at the beginning of the study, 8/13 (62%) had their DKD stage improved, while the other five ones (38%) showed no changes (p < 0.05).ConclusionOur pilot study suggests an association between VD high dose supplementation, lower prevalence and improvement in stages of DKD in T1DM.