Impact Factor 3.675

The 2nd most cited open-access journal in Endocrinology & Metabolism

Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Endocrinol. | doi: 10.3389/fendo.2018.00061

Granulosa cell apoptosis in the ovarian follicle- a changing view

 Sheena L. Regan1*, Phil G. Knight2,  John L. Yovich3, Yee Leung4,  Frank Arfuso1 and  Arun Dharmarajan1
  • 1Stem Cell and Cancer Biology Laboratory, School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Australia
  • 2University of Reading, United Kingdom
  • 3Pivet Medical Center, Australia
  • 4King Edward Memorial Hospital, Australia

Recent studies challenge the previous view that apoptosis within the granulosa cells of the maturing ovarian follicle is a reflection of aging and consequently a marker for poor quality of the contained oocyte. On the contrary, apoptosis within the granulosa cells is an integral part of normal development and has limited predictive capability regarding oocyte quality or the ensuing pregnancy rate in IVF programmes. This review article covers our revised understanding of the process of apoptosis within the ovarian follicle, its three phenotypes, the major signalling pathways underlying apoptosis as well as the associated mitochondrial pathways.

Keywords: Apoptosis signaling, ovarian reserve, ageing effects, Fertility Preservation, FSHR, Bone Morphogenetic Proteins, mitogenic growth, Granulosa Cells, Bax, BCL2

Received: 02 Nov 2017; Accepted: 12 Feb 2018.

Edited by:

David G. Mottershead, Keele University, United Kingdom

Reviewed by:

Abir Mukherjee, Royal Veterinary College, United Kingdom
Livio Casarini, University of Modena and Reggio Emilia, Italy
Jing Xu, Oregon Health & Science University, United States  

Copyright: © 2018 Regan, Knight, Yovich, Leung, Arfuso and Dharmarajan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Sheena L. Regan, Curtin University, Stem Cell and Cancer Biology Laboratory, School of Biomedical Sciences, Curtin Health Innovation Research Institute, Bentley, Australia, sheenaregan@aapt.net.au