AUTHOR=Garcia de la Serrana Daniel , Macqueen Daniel J. 

TITLE=Insulin-Like Growth Factor-Binding Proteins of Teleost Fishes

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 9 - 2018

YEAR=2018

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2018.00080

DOI=10.3389/fendo.2018.00080

ISSN=1664-2392

ABSTRACT=The insulin-like growth factor (IGF) binding protein (IGFBP) family has a broad range of physiological functions and a fascinating evolutionary history. This review focuses on the IGFBPs of teleost fishes, where genome duplication events have diversified gene repertoire, function and physiological regulation - with six core IGFBPs expanded into a family of over twenty genes in some lineages. In addition to briefly summarizing the current state of knowledge on teleost IGFBP evolution, function and expression-level regulation, we highlight gaps in our understanding, and promising areas for future work.