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This article is part of the Research Topic

Classic and Pleiotropic Actions of Vitamin D

Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Endocrinol. | doi: 10.3389/fendo.2019.00103


Irina Zakharova1, Leonid Klimov2*,  Victoria Kuryaninova2*, Irina Nikitina3, Svetlana Malyavskaya4,  Svetlana Dolbnya2, Anna Kasyanova1, Roza Atanesyan2, Marina Stoyan2, Anastasiya Todieva3, Galina Kostrova4 and  Andrey Lebedev4
  • 1Russian Medical Academy of Postgraduate Education, Russia
  • 2Stavropol State Medical University, Russia
  • 3Almazov National Medical Research Centre, Russia
  • 4Northern State Medical University, Russia

Excessive body weight and obesity in childhood and adolescence are becoming more and more important unfavourable factors that entail extremely adverse consequences and require close attention of physicians of any specialty. Along with the high prevalence of obesity and metabolic syndrome in paediatric patients, children and adolescents in the majority of countries are diagnosed with vitamin D deficiency. Among the non-calcaemic effects of vitamin D, a significant role is played by its impact on the hormonal regulation of glucose metabolism and the synthesis of adipokines by fat tissue. The review presents literature data indicative of a close pathogenic relationship between vitamin D insufficiency and impaired tissue insulin sensitivity. It demonstrates the role of vitamin D insufficiency in immune reactions resulting in development of subclinical inflammation in fat tissue infiltrated with macrophages and lymphocytes. It also shows the role of adipokines, immune system cells and pro-inflammatory cytokines produced by them in the pathogenesis of obesity, as well as the function of vitamin D as an endocrine and paracrine regulator of the process of inflammation in adipose tissue. The relationships between the principal adipokines (leptin, adiponectin, resistin) are revealed in the presence of normal vitamin D content and in vitamin D deficiency. The carbohydrate and lipid metabolism parameters in overweight children and adolescents with vitamin D insufficiency are analyzed. A high prevalence of vitamin D insufficiency in overweight and obese children and adolescents (increasing along with the severity of obesity) is demonstrated. The review also presents the current recommendations for the correction of vitamin D insufficiency and underlines the need for higher cholecalciferol doses to achieve serum calcifediol targets in overweight and obese children and adolescents.

Keywords: child obesity, Vitamin D, vitamin D and obesity, vitamin D and obesity in children, adipose tissue and autoimmune inflammation

Received: 07 May 2018; Accepted: 04 Feb 2019.

Edited by:

Jerzy Konstantynowicz, Medical University of Bialystok, Poland

Reviewed by:

Francesca Marta Elli, University of Milan, Italy
Sekib Sokolovic, University of Sarajevo, Bosnia and Herzegovina  

Copyright: © 2019 Zakharova, Klimov, Kuryaninova, Nikitina, Malyavskaya, Dolbnya, Kasyanova, Atanesyan, Stoyan, Todieva, Kostrova and Lebedev. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
MD, PhD. Leonid Klimov, Stavropol State Medical University, Stavropol, Russia,
MD, PhD. Victoria Kuryaninova, Stavropol State Medical University, Stavropol, Russia,