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Front. Endocrinol. | doi: 10.3389/fendo.2019.00457

Iodine and Myo-Inositol: a novel promising combination for iodine deficiency

  • 1Azienda USL Toscana nord ovest Livorno, Italy
  • 2Medical Affairs Department, Lo.Li. Pharma International, Italy
  • 3Department of Experimental Medicine, Faculty of Medicine and Dentistry, Sapienza University of Rome, Italy

Despite universal salt iodization programmes implemented over the last decades, iodine deficiency remains a major public health problem in many countries worldwide. Endeavors are still required to ensure sufficient iodine intake in the populations at risk in order to eliminate deficiency. Iodine is crucial for the synthesis of thyroid hormones triiodothyronine (T3) and thyroxine (T4), as well as for the thyroid health. When iodine levels are insufficient, T4 attests towards the lower limit of the physiological range, causing subtle fluctuations in the T3:T4 ratio. Monitoring these variations may be an accurate way to assess patient’s iodine status. Recently, a number of published clinical studies documented a growing interest toward the use of myo-inositol in thyroid diseases. Myo-inositol, a carbocyclic polyol, regulates the generation of hydrogen peroxide (H2O2) in thyrocytes, crucial for iodine organification and thyroid hormone biosynthesis. Thus, combined supplementation of iodine and myo-inositol may promote higher iodine availability in thyrocytes improving thyroid functionality. This review presents novel strategies for the diagnosis and the management of iodine deficiency, focusing on the potential role of myo-inositol combined with iodine.

Keywords: iodine deficiency, Iodine, myo-inositol, thyroid, Goiter, Organification

Received: 19 Apr 2019; Accepted: 24 Jun 2019.

Edited by:

Salman Razvi, Newcastle University, United Kingdom

Reviewed by:

Mihaly Mezei, Icahn School of Medicine at Mount Sinai, United States
Angela Leung, University of California, Los Angeles, United States  

Copyright: © 2019 Barbaro, Orrù and Unfer. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: MD. Daniele Barbaro, Azienda USL Toscana nord ovest Livorno, Livorno, 57124, Italy,