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Correction ARTICLE

Front. Endocrinol., 22 August 2019 | https://doi.org/10.3389/fendo.2019.00567

Corrigendum: Transcriptome Analysis Showed a Differential Signature Between Invasive and Non-invasive Corticotrophinomas

Leonardo Jose Tadeu de Araújo1,2, Antonio Marcondes Lerario1,3, Margaret de Castro4, Clarissa Silva Martins4, Marcello Delano Bronstein1,5, Marcio Carlos Machado1,5,6, Ericka Barbosa Trarbach7 and Maria Candida Barisson Villares Fragoso1,6*
  • 1Laboratory of Hormones and Molecular Genetics LIM-42, University of São Paulo Medical School, São Paulo, Brazil
  • 2Laboratory of Quantitative Pathology, Center of Pathology, Adolfo Lutz Institute, São Paulo, Brazil
  • 3Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI, United States
  • 4Internal Medicine Department, Ribeirao Preto Medical School, University of São Paulo, Ribeirao Preto, Brazil
  • 5Neuroendocrine Unit, Division of Endocrinology and Metabolism, University of São Paulo Medical School, São Paulo, Brazil
  • 6Endocrinology Service, AC Cancer Center, São Paulo, Brazil
  • 7Laboratory of Cellular and Molecular Endocrinology LIM-25, University of São Paulo Medical School, São Paulo, Brazil

A Corrigendum on
Transcriptome Analysis Showed a Differential Signature Between Invasive and Non-invasive Corticotrophinomas

by de Araújo, L. J. T., Lerario, A. M., de Castro, M., Martins, C. S., Bronstein, M. D., Machado, M. C., et al. (2017). Front. Endocrinol. 8:55. doi: 10.3389/fendo.2017.00055

In the original article, there was an error. We stated that USP8 genetic abnormalities were not identified in DNA from tumor samples analyzed by microarray technology.

A correction has been made to Abstract, Paragraph Number 1, Lines 18–19.

Somatic mutations in USP8 were also investigated and mutations were identified in six cases.

A correction has been made to Results, Paragraph Number 1.

Before microarray analysis, we performed the screening for mutations in USP8 in our patients, and somatic variants were found in patients #2 and #5 (p.Ser718Pro), #4 (p.Ser718Cys), patients #3 and #6 (p.Pro720Arg), and #9 (p.Pro720Gln). Both mutations were found in heterozygosis and have been previously described (17, 18).

A correction has been made to Discussion, Paragraph Number 1.

In the microarray study cohort, we identified six USP8 mutations in 12 samples (50%). In the patients included in the validation study, we could identify somatic USP8 mutations in 5 (non-invasive corticotrophinomas) out of 18 patients (27.7%). According to Reincke et al. (17) and Perez-Rivas et al. (18), these mutations occur in ≈36% of patients with CD. Interestingly, the presence of USP8 mutations did not interfere in the transcriptome expression analysis results comparing invasive vs. non-invasive tumors and in its validation study.

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

Keywords: Cushing's disease, gene expression, neuroendocrine tumors, microarray, anterior pituitary

Citation: de Araújo LJT, Lerario AM, de Castro M, Martins CS, Bronstein MD, Machado MC, Trarbach EB and Villares Fragoso MCB (2019) Corrigendum: Transcriptome Analysis Showed a Differential Signature Between Invasive and Non-invasive Corticotrophinomas. Front. Endocrinol. 10:567. doi: 10.3389/fendo.2019.00567

Received: 23 May 2019; Accepted: 02 August 2019;
Published: 22 August 2019.

Edited and reviewed by: Nienke Biermasz, Leiden University, Netherlands

Copyright © 2019 de Araújo, Lerario, de Castro, Martins, Bronstein, Machado, Trarbach and Villares Fragoso. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Maria Candida Barisson Villares Fragoso, maria.villares@hc.fm.usp.br