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Front. Endocrinol. | doi: 10.3389/fendo.2019.00725

G protein-coupled estrogen receptor: a potential therapeutic target in cancer

Shen Xu1, Shan Yu2, 3, Daming Dong1* and  Leo T. Lee2, 3*
  • 1First Affiliated Hospital of Harbin Medical University, China
  • 2Centre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, China
  • 3Cancer Centre, Faculty of Health Sciences, University of Macau, China

The G protein-coupled estrogen receptor (GPER) is a seven-transmembrane-domain receptor that mediates non-genomic estrogen related signaling. After ligand activation, GPER triggers multiple downstream pathways that exert diverse biological effects on the regulation of cell growth, migration and programmed cell death in a variety of tissues. A significant correlation between GPER and the progression of multiple cancers has likewise been reported. Therefore, a better understanding of the role GPER plays in cancer biology may lead to the identification of novel therapeutic targets, especially among estrogen-related cancers. Here, we review cell signaling and detail the functions of GPER in malignancies.

Keywords: G protein-coupled estrogen receptor, Cancer, signaling pathway, estrogen, Non-genomic estrogen signaling

Received: 14 Aug 2019; Accepted: 09 Oct 2019.

Copyright: © 2019 Xu, Yu, Dong and Lee. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Prof. Daming Dong, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China, dongdaming1965@hotmail.com
Dr. Leo T. Lee, Centre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, Macau, Shanghai Municipality, China, ltolee@umac.mo