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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Endocrinol. | doi: 10.3389/fendo.2019.00792


 Saartje Straetemans1, 2, 3*, Jean De Schepper3, 4, 5, Muriel Thomas3, Sylvie Tenoutasse3, 6, Véronique Beauloye3, 7 and  Raoul Rooman3, 8
  • 1Department of Pediatric Endocrinology, Maastricht University Medical Centre, Netherlands
  • 2School of Nutrition and Translational Research in Metabolism, Faculty of Health, Medicine and Life Sciences, Maastricht University, Netherlands
  • 3Other, Belgium
  • 4Department of Pediatric Endocrinology, University Hospital Brussels, Belgium
  • 5Department of Pediatric Endocrinology, Ghent University Hospital, Belgium
  • 6Department of Pediatric Endocrinology, Queen Fabiola Children's University Hospital, Belgium
  • 7Department of Pediatric Endocrinology, Cliniques Universitaires Saint-Luc, Belgium
  • 8Other, Belgium

Several criteria for first-year growth response (FYGR) to growth hormone (GH) treatment have been proposed. We explored which FYGR criteria predicted best the final height outcome after GH treatment in prepubertal children with GH deficiency (GHD).
Design and methods:
Height data of 129 GHD children (83 boys) who attained adult height and had been treated with GH for at least 4 consecutive years with at least one year before pubertal onset, were retrieved from the Belgian GH Registry. The FYGR parameters were: (1) increase in height (∆Ht) SDS, (2) height velocity (HV) SDS, (3) ∆HV (cm/year), (4) index of responsiveness (IoR) in KIGS prediction models, (5) first-year HV SDS based on the KIGS expected HV curve (HV KIGS SDS), (6) near final adult height (nFAH) prediction after first-year GH treatment. Poor final height outcome (PFHO) criteria were: (1) total ∆Ht SDS <1.0, (2) nFAH SDS <-2.0, (3) nFAH minus midparental height SDS <-1.3. ROC curve analyses were performed to define the optimal cut-off for FYGR parameters. Only ROC curves with an area under the curve (AUC) >70% were further analyzed.
Twelve, 22 and 10% of the children had respectively a total ∆Ht SDS <1, nFAH SDS <-2, and nFAH minus midparental height SDS <-1.3. The AUC’s ranged between 73 and 85%. The highest AUC was found for first-year ∆Ht SDS to predict total ∆Ht SDS <1, and predicted nFAH SDS to predict nFAH SDS <-2. The currently used FYGR criteria had low specificities and sensitivities to detect PFHO. To obtain a 95% specificity, the cut-off value (and sensitivity) of FYGR parameters were: ∆Ht SDS <0.35 (40%), HV SDS <-0.85 (43%), ∆HV <1.3 cm/year (36%), IoR <-1.57 (17%), HV KIGS SDS <-0.83 (40%) to predict total ∆Ht SDS <1; predicted nFAH SDS (with GH peak) <-1.94 (25%), predicted nFAH SDS (without GH peak) <-2.02 (25%) to predict nFAH SDS <-2. At these cut-offs, the amount of correctly diagnosed poor final responders equals the amount of false positives.
First-year growth response criteria perform poorly as predictors of poor final height outcome after long-term GH treatment in prepubertal GHD children.

Keywords: growth hormone treatment, growth hormone deficiency, first-year growth response criteria, Children, adult height outcome

Received: 01 Jul 2019; Accepted: 30 Oct 2019.

Copyright: © 2019 Straetemans, De Schepper, Thomas, Tenoutasse, Beauloye and Rooman. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Saartje Straetemans, Maastricht University Medical Centre, Department of Pediatric Endocrinology, Maastricht, Netherlands,