AUTHOR=Ghasemi Marzieh , Aleyasin Ashraf , Fatemi Human M. , Ghaemdoust Faezeh , Shahrakipour Mahnaz 

TITLE=Uterine Cavity Irrigation With Office Hysteroscopy During Ovarian Stimulation for IVF: A Randomized Controlled Trial

JOURNAL=Frontiers in Endocrinology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.778988

DOI=10.3389/fendo.2022.778988

ISSN=1664-2392

ABSTRACT=Abstract:
Objective: This was a non-blinded randomized controlled study to evaluate whether endometrial irrigation via office hysteroscopy during the early follicular phase would lead to a higher level of live birth rates compared to no irrigation in the fresh embryo transfer cycle. 
Method: The study was conducted in Tehran university of medical sciences from June 2015 to June 2016. women under the age of 40 with primary infertility without history of previous IVF/ICSI or hysteroscopic examination, were included. Controlled ovarian hyperstimulation was done. Hysteroscopy was performed in the early mid-follicular phase of a stimulation cycle (day 5-7) with a vaginoscopy approach and saline irrigation in hysteroscopy group. Embryo-transfer was done in the same cycle. 
Results: 228 patients completed their participation in the study. In the fresh cycle, clinical pregnancy rate was 46 % in the hysteroscopy group and 40.43 % in the control group. (p-value= 0.326, RR= 1.16  [95%CI: 0.862 to 1.56]). Live birth rate was 41.28% in the hysteroscopic group and 31.93% in the control group (p-value=0.143, RR= 1.293  [95%CI: 0.916 to 1.825]). For those patients having surplus cryopreserved embryos, after 2 months, a second embryo transfer was performed. The cumulative LBR was 44.05% in the hysteroscopic group and 32.25% in the control group (p-value=0.029, RR= 1.368 [95%CI: 1.031 to 1.815], RD= 11.9%  [95%CI: 1.2% to 22.3%] and NNT= 8 [95%CI: 4 to 85]). 
Conclusion: The current study clearly demonstrated  a significantly higher  cumulative live birth rate in the intervention group.