Perioperative hormone level changes and their clinical implications in patients with pituitary adenoma: a retrospective study of 428 cases at a single center

Objective This study employs case data analysis to elucidate alterations in hormone levels pre and post-surgery among patients with pituitary adenoma. Moreover, it investigates the influence of various associated factors on endocrine function. Methods A retrospective analysis was conducted on clinical data from 428 patients who underwent surgical treatment within a short period at a single center. Statistical methods were employed to examine detailed hormone level fluctuations before and after surgery in patients with pituitary adenoma, along with their interrelations with different factors. Results Between January 2016 and October 2022, a total of 428 consecutive patients with pituitary adenoma underwent surgical treatment. Of these, 232 were males and 196 were females, with an average age of 45.91 years (range: 16-84, standard deviation: 12.18). Univariate analysis indicated that females exhibited a higher susceptibility to preoperative endocrine dysfunction (p < 0.05). Conversely, males, patients with larger tumor volumes, and older patients were more prone to preoperative pituitary insufficiency. Postoperatively, the most substantial remission rate occurred in prolactin (77.4%), followed by growth hormone (GH) (71.8%) and cortisol (4/6). The highest recovery rate in functions was observed in growth hormone secretion function (80%), followed by pituitary-adrenal axis hormone secretion function (56.3%) and pituitary-thyroid axis hormone secretion function (47.5%). The most noteworthy incidence of newly developed postoperative endocrine deficiencies was found in the pituitary-adrenal axis (31.8%), while the occurrence rates of deficiencies in other axes were relatively low. The elevated postoperative remission rate of growth hormone correlated with a higher surgical resection rate and lower preoperative growth hormone levels. Additionally, lower preoperative prolactin levels corresponded to a higher remission rate of prolactin postoperatively. Furthermore, the restoration of postoperative thyroid hormone secretion function was associated with higher preoperative free thyroxine levels. Reduced postoperative cortisol secretion function was linked to multiple surgeries and an extended interval between hormone retesting and surgery. Conclusion Surgical intervention effectively ameliorates endocrine disorders in pituitary adenoma patients, thereby mitigating symptoms and enhancing their quality of life. Preoperative management of growth hormone and prolactin levels facilitates an increased remission rate of these hormones post pituitary adenoma surgery. Patients displaying preoperative thyroid hormone secretion dysfunction should be considered for active supplementation therapy. Whenever feasible, complete tumor resection is recommended. For patients undergoing reoperation or multiple surgeries, vigilant postoperative cortisol monitoring and supplementation should be thoughtfully administered.


Introduction
Pituitary adenomas rank among the three most prevalent intracranial tumors.Predominantly benign, they account for approximately 12% of all intracranial neoplasms.Most are nonfunctional adenomas, primarily causing symptoms through mass effect and compression.This is evident in presentations such as headaches, vomiting, visual field deficits, and diminished vision.A minority are functional adenomas, characterized by symptoms arising from endocrine hormonal dysregulation.Depending on the specific hormonal disruption, they may manifest various symptoms including amenorrhea, galactorrhea, polydipsia, polyuria, central obesity, acromegaly, and gigantism etc.These symptoms have a substantial impact on the patient's quality of life.Therefore, following a confirmed diagnosis, the majority of cases necessitate proactive interventions including medication, surgical procedures, gamma knife therapy, and other pertinent treatments.
Studies focusing on cases exhibiting preoperative pituitary function within the normal range followed by subsequent postoperative dysfunction are notably limited (n < 50), and their duration extends significantly (12 years), (2) potentially introducing systematic errors related to measurement devices, diagnostic standards, and therapeutic approaches.Consequently, this approach might not accurately capture the factors influencing postoperative cortisol variations within the current context of continually progressing diagnostic and therapeutic standards.
In this investigation, we undertook a retrospective analysis of 428 cases involving surgically treated pituitary adenomas at a singular medical center spanning an 80-month period.Our primary objective was to delve into the alterations in hormone levels prior to and subsequent to surgery among patients with pituitary adenoma.Furthermore, we sought to elucidate potential factors that could exert influence, aiming to provide valuable clinical insights.

Inclusion criteria
Patients with pathologically confirmed pituitary adenomas who underwent surgical treatment at Peking University International Hospital between January 2016 and October 2022 were consecutively enrolled.Basic demographic information, preoperative and postoperative hormone test results, clinical data before surgery, tumor size, surgical specifics, postoperative pathological classification, and clinical data were extracted from electronic medical records.Cases without hormone level test results pre-operation or within one week after surgery were excluded.Cases with missing imaging data for post-operative review were excluded.A statistical analysis was conducted to assess changes in serum hormone levels before and after surgery, along with their influencing factors.

Endocrine assessment
Preoperative and postoperative endocrine evaluations were performed in the hospital's laboratory.Serums were collected before rising in the morning, immunoassays were utilized to measure hormones in the serums related to the pituitary-adrenal axis, pituitary-thyroid axis, pituitary-gonadal axis, serum prolactin, and growth hormone.
The evaluation of the pituitary-adrenal axis was based on serum cortisol concentration (normal range: 6.24-18.00mg/dL in the morning, 2.69-10.40mg/dL in the afternoon).Cortisol deficiency was defined as a serum cortisol concentration <6.24 mg/dL, while cortisol excess was defined as >18.0 mg/dL.
Assessment of the pituitary-gonadal axis considered gender, age, serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol, and testosterone concentrations.Dysfunction of this axis was determined based on hormone levels and age.
Assessment of reduced antidiuretic hormone (ADH) secretion required a urine volume ≥40 mL/kg/day and urine osmolality <300 mOsm/kg.Due to a lack of relevant quantitative data, further discussion on ADH secretion reduction was omitted.
Pituitary deficiency was defined by the presence of one of the following conditions: global pituitary deficiency (deficiency in all axes), single-axis deficiency (deficiency in any single axis), two-axis deficiency (deficiency in two axes), or three-axis deficiency (deficiency in three axes).

Postoperation hormone changes
All patients underwent postoperative serum hormone level reassessment within one week, with blood samples collected between 6:00 and 8:00.Methylprednisolone sodium succinate (methylprednisolone) intravenous infusions of 0-80 mg were administered on the surgery day, followed by additional doses for the subsequent three days.Given methylprednisolone's short half-life (1.9-5.4 hours), its impact on morning serum cortisol measurements was deemed negligible (19)(20)(21).Postoperative hormone changes were classified as follows: a) Recovery: Normalization of previously deficient axes postoperatively.b) Remission: Normalization or reduction of previously elevated axes postoperatively (22).c) Deficiency: Transition of previously normal axes to deficiency postoperatively.

Imaging evaluation
All patients underwent 3.0T cranial magnetic resonance imaging (MRI) scans (5mm slice thickness) before and after surgery at our institution.For certain microadenoma cases, dynamic enhanced scans of the sellar region were conducted before surgery to ascertain tumor size and location.Evaluation of tumor characteristics, encompassing size and hemorrhage occurrence, was performed by at least one neuroimaging specialist and multiple neurosurgeons.Tumor size was categorized as microadenoma (maximum diameter d ≤ 10mm), macroadenoma (10mm<d ≤ 30mm), and giant adenoma (d>30mm).Postoperative imaging assessments determined tumor resection extent, classified as gross total resection (Figures 1A, B), near-total resection (resection≧90%, Figures 2A, B), or partial resection(resection<90%).

Tumor resection surgery
Tumor resection surgeries were conducted by experienced neurosurgeons with over a decade of expertise at our center.The choice of surgical approach-transcranial (Figure 2A) or endonasal transsphenoidal (Figure 1A)-was predicated on tumor size, location, and other considerations.Surgeries were guided by microscopy or neuroendoscopy.The primary objective was maximal tumor resection, while mindful of scenarios where tumor proximity to vital nerves, vessels, or normal pituitary tissue necessitated restraint.Instances of intraoperative sellar floor disruption or cerebrospinal fluid (CSF) leakage during endonasal transsphenoidal approaches entailed repair utilizing autologous fat and muscle with bioadhesive.In minor leakage cases, gelatin sponge and bioadhesive were employed.Data compilation encompassed surgical approach details, procedure duration, occurrences of intraoperative CSF leakage, need for blood transfusion, and postoperative localized hematoma events.

Statistical analysis
Statistical analysis employed IBM SPSS Statistics version 19.0.Descriptive analysis encompassed patient characteristics with preoperative hypofunction, normal function, or hyperfunction of each axis.The relationship between these characteristics and clinical factors was examined through univariate analysis.Similarly, descriptive analysis was applied to patients with postoperative recovery, improvement, or deterioration of endocrine function in each axis.Independent sample univariate analysis was conducted to identify potential factors influencing postoperative changes.Numerical variables (e.g., age, maximum tumor diameter, surgical duration) were subjected to t-tests, analysis of variance (if normally distributed), or Mann-Whitney U tests (if not normally distributed).Categorical variables (e.g., gender, age stratification, tumor pathology, surgical approach, surgical duration stratification) were analyzed using chi-square tests or Fisher's exact probability method.Finally, logistic regression analysis was performed on variables with P<0.05 in univariate analysis to ascertain potential influencing factors for postoperative recovery, improvement, or deterioration of endocrine function in pituitary adenoma patients.

Basic patient characteristics
Between January 2016 and October 2022, a total of 428 patients with pituitary adenomas underwent surgical treatment, with 54.2% being male and 45.8% female.The average age was 45.91 years (range: 16-84, standard deviation 12.18).The summarized general characteristics can be found in Table 1.Among these patients, 253 presented with visual impairments, 136 reported headaches, 75 exhibited acromegaly, 9 displayed signs of Cushing's syndrome, 60 had undergone prior surgeries (52 cases once, 8 cases twice), 40 had a history of diabetes, and 94 had hypertension.No patients had received previous radiation therapy.Effective cases for each endocrine axis (including growth hormone and prolactin) are presented in Table 2, excluding cases without preoperative or within one-week postoperative hormone test results.Among these, 412 cases involved the pituitary-adrenal axis, 401 cases the pituitary-thyroid axis, 341 cases the pituitary-gonadal axis, 415 cases had assessable growth hormone secretion, and 417 cases had assessable prolactin secretion.The male-to-female ratio was nearly balanced, with a slight preponderance of males.

Preoperative pituitary endocrine function
Prior to surgery, a total of 11 cases (2.5%) exhibited combined low function of the pituitary-adrenal, pituitary-thyroid, and pituitary-gonadal axes.Among these, two cases underwent serum IGF-1 level testing, both yielding results below the normal range.Among the 11 patients, one case displayed elevated serum growth hormone levels (16.4 ng/ml, male) with no available IGF-1 test results.Excluding this growth hormone elevation, 10 cases (2.3%) had preoperative growth hormone secretion deficiency.

Preoperative clinical symptoms and relevant examination results
From Table 4, it is evident that among the 155 patients with preoperative symptoms of menstrual disorders, galactorrhea, or sexual dysfunction, only 40.6% had elevated serum prolactin levels.The majority (53.5%) had normal serum prolactin levels, with a mean of 65.33 ng/ml (range: 0.4-2125, standard deviation 238.83).To mitigate the influence of outliers, a truncated mean of 28.26 ng/ ml was calculated to represent the central tendency of preoperative serum prolactin levels.Among these 155 patients, a lower proportion (14.2%) exhibited deficiency in the pituitary-gonadal

Analysis of preoperative pituitary function factors
Among the cases mentioned earlier, it is evident that while 101 cases (23.6%) exhibited normal preoperative pituitary hormone levels, the remaining cases displayed various endocrine disturbances.Out of the total cases, 126 (29.6%) had deficiencies in at least one pituitary axis (excluding hypoprolactinemia), while the rest had normal function.Results from Tables 5, 6 reveal a gender-related association with preoperative endocrine disturbances (p < 0.05), with a higher prevalence in females (81.6%) compared to males (72.0%).Factors such as age, previous surgical history, presence of hypertension and diabetes, tumor size, tumor pathology, and tumor-related hemorrhage did not show significant relationships.Tables 7 and 8 indicate that preoperative pituitary dysfunction (any axis) is related to gender, tumor size, and age.Female patients, those with larger tumor volumes, and older individuals were more prone to pituitary dysfunction.Additionally, there seems to be a potential link between a history of prior hospitalization (p = 0.053) and pituitary dysfunction occurrence.

Postoperative changes in pituitary endocrine function
As depicted in Table 10, among the 420 cases with hormone retests within 7 days postoperatively, 59 cases (46.8%) of the 126 patients with preoperative deficiency in at least one endocrine axis experienced recovery of at least one axis.Among the 144 patients with preoperative elevation of at least one pituitary axis hormone, 92 cases (63.9%) achieved hormone relief.Among the 410 patients with no deficiency in any preoperative endocrine axis, 127 cases (31.0%) developed new-onset deficiency in at least one axis.
In terms of individual endocrine axes, the highest recovery rate was observed for pituitary growth hormone secretion, with 8 out of 10 cases of preoperative growth hormone deficiency showing postoperative recovery.The next highest relief rate was seen for the pituitary-adrenal axis (56.3%) and pituitary-thyroid axis (47.5%).Prolactin exhibited the highest hormone relief rate (77.4%), followed by pituitary growth hormone (71.8%) and cortisol.Among the 6 cases with preoperative hypercortisolism, 4 cases achieved normalization of cortisol levels postoperatively.The highest rate of new-onset postoperative deficiency occurred in the pituitary-adrenal axis (31.8%), while the occurrence rates for other axes were relatively lower.In the univariate analysis (Tables 11, 12), postoperative relief of pituitary growth hormone was linked to tumor size, extent of surgical resection, age, and preoperative GH values (P < 0.05).However, it did not correlate with gender, history of prior hospitalization, tumor type, tumor-related hemorrhage, surgical approach, or operation duration.Smaller tumor diameters, greater rates of tumor resection, older age, and lower preoperative growth hormone values were associated with higher relief rates.Moreover, elevated preoperative FT4, FSH, and LH hormone levels, along with reduced preoperative PRL levels, were indicative of enhanced postoperative growth hormone relief rates (P < 0.05).Multivariate logistic regression analysis (Table 13) confirmed that postoperative growth hormone relief correlated with the extent of surgical resection and preoperative GH levels.

Prolactin relief
Analysis from Tables 11 and 12 revealed that, in the univariate analysis, postoperative prolactin relief was linked to tumor-related hemorrhage, age, and preoperative PRL levels, while showing no connection to tumor pathology, size, or extent of surgical resection.The absence of tumor-related hemorrhage, advanced age, and lower preoperative PRL hormone levels suggested a higher postoperative prolactin relief rate.Table 13 demonstrates that, in the multivariate analysis, postoperative prolactin relief was solely associated with preoperative PRL hormone levels.

Adrenal axis
Univariate analysis (Supplementary Tables 1, 2) indicated that postoperative recovery of pituitary-adrenal axis function had no correlation with tumor pathology, tumor size, extent of surgical resection, or preoperative hormone levels.Postoperative Site Hemorrhagea a 8 (1.9) a Including 6 cases of transcranial surgery and 2 cases of craniotomy.

Thyroid axis
Univariate analysis of predictive factors for recovery of pituitary-thyroid axis function (Supplementary Tables 1, 2) demonstrated an association with preoperative FT4 levels and the number of deficient axes.Tumor size, pathology, and surgical variables had no impact on recovery rate.Higher preoperative FT4 levels and fewer preoperative deficient axes were linked to easier recovery of pituitary-thyroid axis function.Logistic regression analysis of these factors yielded a significance level of P = 0.004 < 0.05 for preoperative FT4, with B = 2.842, indicating consistent  significance.However, the number of preoperative deficient axes had a P value of 0.070 > 0.05, suggesting no effect on recovery of pituitary-thyroid axis function.
3.9 Factors influencing new-onset postoperative deficiency

Adrenal axis
In the univariate analysis (Supplementary Tables 3, 4), the development of new-onset pituitary-adrenal axis deficiency postoperatively was influenced by a history of prior hospitalization and the interval between hormone retest and surgery.Patients with a history of previous surgery were more prone to experiencing newonset pituitary-adrenal axis deficiency after surgery.Additionally, an extended interval between hormone retest and surgery was associated with a higher incidence of new-onset pituitary-adrenal axis deficiency within 7 days postoperatively.Multivariate analysis affirmed the significance of both factors with P values < 0.001, consistent with univariate analysis.The occurrence of new-onset pituitary-adrenal axis deficiency postoperatively was not tied to tumor size, type, or extent of surgical resection.

Thyroid axis
Univariate analysis regarding new-onset pituitary-thyroid axis deficiency after surgery (Supplementary Tables 3, 4) indicated a sole dependence on the preoperative FT4 level.Lower preoperative FT4 levels were associated with a higher likelihood of new-onset deficiency in the pituitary-thyroid axis postoperatively, without any connection to tumor size, surgical approach, or extent of surgical resection.

Baseline characteristics
With the continuous advancement of medical technology and improvements in surgical skills, the effectiveness of surgical treatment for pituitary adenomas has significantly improved, leading to reduced complications (23)(24)(25).Mortality and disability rates have reached extremely low levels.Consequently, the evaluation of surgical outcomes in patients undergoing tumor resection primarily centers on the enhancement of postoperative quality of life, which is closely linked to the restoration of normal pituitary endocrine function.
This study's subjects encompassed pituitary adenoma cases treated at a single center, benefiting from consistent medical expertise over a relatively brief time span.Minimized influence of medical and surgical techniques on outcomes ensured robust data stability and comparability.Hence, the study offers a reasonably dependable representation of postoperative hormone effects resulting from microscopic and endoscopic surgical interventions, adhering to current medical standards.

Potential factors affecting preoperative endocrine
Status The presence of preoperative endocrine disorders in pituitary adenoma patients exhibited a connection with gender (P < 0.05), attributing a higher likelihood to females.No substantial associations emerged with age, prior surgery history, hypertension, diabetes, underlying conditions, tumor dimensions, pathology, or tumor-related hemorrhage.This suggests that preoperative endocrine dysfunction in pituitary adenoma patients might bear a certain degree of randomness, not exclusively governed by tumor characteristics or disease progression.
Incidence of deficiency in any pituitary function axis prior to surgery correlated with gender, tumor size, and age.Male patients, those with larger tumor volumes, and older individuals faced a heightened risk of pituitary dysfunction.The frequency of pituitary target organ axis dysfunction was linked to tumor size, indicating that larger tumors exert more pressure on the normal pituitary, thus impeding its function.Furthermore, since the sample excluded children, older patients displayed more pronounced degradation of normal pituitary function due to age and heightened susceptibility to tumor-associated functional deficits.The correlation between acromegaly and elevated growth hormone levels was remarkably strong, whereas patients with Cushing's syndrome didn't universally exhibit cortisol levels exceeding the upper normal range.Nevertheless, their levels remained relatively elevated within the range, aligning with clinical observations.The clinical manifestations of patients experiencing preoperative menstrual disorders, galactorrhea, or sexual dysfunction weren't entirely elucidated by preoperative gonadal function and serum prolactin levels.However, the average serum prolactin level stood at 28.26 ng/ml, surpassing the upper normal limit, underscoring a close link between these symptoms and elevated serum prolactin levels, consistent with clinical observations.

Postoperative hormonal changes and influential factors
Examining postoperative hormone level shifts in pituitary adenoma patients-owing to their significant physiological impact and potential to affect quality of life-primarily centered on serum prolactin, growth hormone, cortisol relief, adrenal cortical function recovery, thyroid function recovery, gonadal function recovery, and incidence of new-onset cortisol and thyroid deficiency following surgery.
Our data demonstrates relatively high relief rates for serum prolactin, growth hormone, and cortisol after microscopic tumor resection (77.4%, 71.8%, and 66.7% respectively).Surgery significantly improved these endocrine imbalances, considerably impacting patients' physical well-being.Gonadal axis hormone recovery after surgery proved less satisfactory, yet the prolactin relief rate at 77.4% offers sustained alleviation for symptoms like menstrual disorders and gonadal dysfunction.Prior studies indicated that factors affecting hormone relief post pituitary adenoma surgery encompassed age, preoperative hormone levels, tumor volume, tumor invasiveness, residual post-surgery tumor, and postoperative early-morning hormone levels (2, 5, 9, 10).Multifactorial analysis herein underscores that surgical resection rate (reflecting extent of tumor residue) and preoperative GH levels influence the recovery rate of growth hormone post-surgery.Singlefactor analysis also suggests potential relevance of tumor size and age.For prolactin relief post-surgery, the pivotal factor remains preoperative PRL levels.Single-factor analysis hints at possible influence of tumor-related hemorrhage and patient age on relief rate.Limited data availability precluded an analysis of tumor invasiveness (26).These findings emphasize the significance of actively managing GH and PRL levels preoperatively, striving for maximal tumor resection to enhance relief rates for growth hormone and prolactin in postoperative pituitary adenoma patients.
Approximately half of patients with preoperative adrenal cortical dysfunction and thyroid dysfunction witnessed recovery (56.3% and 47.5% respectively).Most cases displayed varying hormone level elevation, notably enhancing patient quality of life.Earlier studies suggested recovery of pituitary target organ axis function in pituitary adenoma patients hinges on tumor size, patient age (27,28), presence of intraoperative cerebrospinal fluid leakage, and tumor endocrine function (1).Yet, these studies didn't differentiate recovery status of specific hormone secretions.We find that recovery of cortisol secretion function post-surgery isn't significantly associated with patient age, tumor size, tumor function, surgical resection rate, or preoperative hormone levels.Advancements in diagnosis and treatment likely mitigate previous factors' impact.Recovery of thyroid hormone secretion function post-surgery associates with higher preoperative FT4 levels, indicating enhanced likelihood of recovery for patients with less compromised function.Hence, patients with preoperative thyroid dysfunction are encouraged to seek treatment when tumor impact on pituitary-thyroid axis function is minimal.
Incidence rates of new-onset cortisol and thyroid hormone deficiency post-surgery weren't negligible (31.3% and 2.7% respectively), necessitating short-term replacement therapy to sustain fundamental physiological needs and normal function after surgery.While some research suggested new-onset pituitary target organ axis dysfunction post-surgery was influenced by tumor volume (1), this study underscores no correlation between newonset pituitary-adrenal axis or pituitary-thyroid axis dysfunction and tumor size.This likely reflects improved tumor resection techniques' influence on outcomes.Data analysis underscores that new-onset cortisol secretion deficiency post-surgery significantly correlates with previous surgery history and interval between postoperative hormone reevaluation and surgery.This underscores the need for close monitoring and cortisol supplementation after surgery for reoperated patients.Notably, cortisol secretion deficiency onset generally transpires around the second day post-surgery, emphasizing the necessity of multiple cortisol reevaluations over several days.

Conclusion
Microsurgery demonstrates significant efficacy in ameliorating endocrine disturbances in patients afflicted with pituitary adenomas.Among the 428 cases examined in this study, postoperative remission rates for serum prolactin, growth hormone, and cortisol were notably elevated at 77.4%, 71.8%, and 66.7% respectively.Roughly half of the patients with preoperative adrenal insufficiency and thyroid dysfunction (56.3% and 47.5% respectively) exhibited recovery, with a majority achieving endocrine restoration.This confers a markedly positive influence on symptomatology and overall quality of life for individuals afflicted with pituitary adenomas.
The determinants impacting the postoperative remission rate of growth hormone encompass the surgical excision rate and preoperative GH levels.Moreover, the remission rate of prolactin subsequent to surgery correlates with preoperative PRL levels.Consequently, proactive management of GH and PRL levels preoperatively facilitates heightened rates of remission for growth hormone and prolactin post pituitary adenoma resection.
The recuperation of thyroid hormone secretion function postsurgery is closely associated with elevated preoperative FT4 levels.Encouragement is warranted for individuals with pituitary adenomas and preoperative thyroid dysfunction to proactively seek treatment when the tumor exerts a relatively minor impact on the pituitary-thyroid axis function.
Patients subjected to multiple surgeries manifest a heightened susceptibility to postoperative onset of cortisol secretion insufficiency.Therefore, a concerted effort towards comprehensive tumor resection and disease resolution in a singular surgical intervention is advised.Moreover, heightened vigilance should be directed towards postoperative monitoring and supplementation of cortisol for patients undergoing repeated or multiple surgical interventions.

Limitations and future prospects
Given the study's focus on the perioperative period, longer follow-up is warranted to explore long-term effects.For cases where pituitary-gonadal axis function recovery proves suboptimal, a gender-based follow-up study, aft er excluding high prolactinemia's influence, can uncover causal factors.Long-term follow-up for patients with new-onset pituitary-adrenal axis dysfunction post-surgery is essential to ascertain recovery potential, aiding comprehensive patient management and refining treatment strategies.Certain subgroups featured small sample sizes in this study, like cases with preoperative cortisol elevation (only six cases) and those with prior surgery history (only eight cases), constraining advanced statistical analysis and statistical power.For these low-incidence scenarios, accumulating more cases is vital to bolster analysis accuracy.

TABLE 1
Basic characteristics of 428 patients undergoing surgical treatment.

TABLE 2
Effective cases of various axes in 428 cases of surgical treatment.
function were associated with these symptoms.Among the 9 cases with preoperative Cushing's syndrome, only 22.2% had elevated serum cortisol levels, with 77.8% exhibiting normal serum cortisol levels.The mean serum cortisol level was 208.29 ng/ml (range: 79.6-315.0,standard deviation 72.92).However, among the 75 patients with acromegaly, 86.7% had elevated growth hormone levels.

TABLE 4
Comparison of preoperative clinical symptoms and examination results in patients.

TABLE 3
Preoperative hormone status of 428 patients undergoing surgical treatment.
a Excluding cases of elevated prolactin.b Excluding cases of decreased prolactin.

TABLE 5
Impact factors of preoperative endocrine dysfunction: categorical variables.

TABLE 10
Postoperative hormonal changes in cases reexamined within 7 days after surgery.
a Includes cases transitioning from hypofunction to normal or hypofunction to hyperfunction, and vice versa.b "Any Axis" mentioned above excludes prolactin.

TABLE 8
Impact factors of preoperative endocrine hypofunction: numerical variables.

TABLE 11
Predictive factors of hormonal remission after surgery: categorical variables.

TABLE 12
Predictive factors of hormonal remission after surgery: numerical variables.

TABLE 13
Predictive factors of hormonal remission after surgery: multivariate logistic regression.