TY - JOUR AU - Dujon, Antoine M. AU - Boutry, Justine AU - Tissot, Sophie AU - Lemaître, Jean-François AU - Boddy, Amy M. AU - Gérard, Anne-Lise AU - Alvergne, Alexandra AU - Arnal, Audrey AU - Vincze, Orsolya AU - Nicolas, Delphine AU - Giraudeau, Mathieu AU - Telonis-Scott, Marina AU - Schultz, Aaron AU - Pujol, Pascal AU - Biro, Peter A. AU - Beckmann, Christa AU - Hamede, Rodrigo AU - Roche, Benjamin AU - Ujvari, Beata AU - Thomas, Frédéric PY - 2022 M3 - Systematic Review TI - Cancer Susceptibility as a Cost of Reproduction and Contributor to Life History Evolution JO - Frontiers in Ecology and Evolution UR - https://www.frontiersin.org/articles/10.3389/fevo.2022.861103 VL - 10 SN - 2296-701X N2 - Reproduction is one of the most energetically demanding life-history stages. As a result, breeding individuals often experience trade-offs, where energy is diverted away from maintenance (cell repair, immune function) toward reproduction. While it is increasingly acknowledged that oncogenic processes are omnipresent, evolving and opportunistic entities in the bodies of metazoans, the associations among reproductive activities, energy expenditure, and the dynamics of malignant cells have rarely been studied. Here, we review the diverse ways in which age-specific reproductive performance (e.g., reproductive aging patterns) and cancer risks throughout the life course may be linked via trade-offs or other mechanisms, as well as discuss situations where trade-offs may not exist. We argue that the interactions between host–oncogenic processes should play a significant role in life-history theory, and suggest some avenues for future research. ER -